HCNSO Student Theses and Dissertations

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Defense Date

7-1980

Document Type

Thesis - NSU Access Only

Department

Oceanographic Center

First Advisor

Barbara B. Jacobs

Abstract

C-reactive protein, a normally occurring plasma protein, may become elevated as much as 3,000-fold during disease states involving acute inflammation or tissue damage. Through its binding to phosphorylcholine, in the presence of calcium, C-reactive protein has been shown to potentiate the activation of the classical and alternative complement pathways and stimulate phagocytosis as well as inhibit certain platelet and T cell reactivities. Its interaction with the various substances that are an integral part of immunological surveillance implies an important role for C-reactive protein in the host reaction to defense, disease and inflammation. The possible significance of this role is discussed.

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