Marine & Environmental Sciences Faculty Articles
Document Type
Article
Publication Date
2008
Publication Title
Marine Drugs
Keywords
Okadaic acid, Polyketide, Polyketide synthase, Biosynthesis, Roseobacter
ISSN
1660-3397
Volume
6
Issue/No.
2
First Page
164
Last Page
179
Abstract
Okadaic acid (OA) and the related dinophysistoxins are isolated from dinoflagellates of the genus Prorocentrum and Dinophysis. Bacteria of the Roseobacter group have been associated with okadaic acid producing dinoflagellates and have been previously implicated in OA production. Analysis of 16S rRNA libraries reveals that Roseobacter are the most abundant bacteria associated with OA producing dinoflagellates of the genus Prorocentrum and are not found in association with non-toxic dinoflagellates. While some polyketide synthase (PKS) genes form a highly supported Prorocentrum clade, most appear to be bacterial, but unrelated to Roseobacter or Alpha-Proteobacterial PKSs or those derived from other Alveolates Karenia brevis or Crytosporidium parvum.
Additional Comments
National Institute of Environmental Health Sciences grant #s: S11 ES11181, P50 ES12736-01; NSF grant #: 0432368; USDA grant #: NRICGP 2002-35201-11671
NSUWorks Citation
Perez, Roberto, Li Liu, Jose Lopez, Tianying An, and Kathleen S. Rein. "Diverse bacterial PKS sequences derived from okadaic acid-producing dinoflagellates." Marine drugs 6, no. 2 (2008): 164-179.
ORCID ID
0000-0002-1637-4125
ResearcherID
F-8809-2011
DOI
10.3390/md20080009
Comments
©2008 by the author(s); licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).