Platelet Satellitism and Dual Surface Immunoglobulin Light-Chain Expression in Circulating Splenic Marginal Zone Lymphoma Cells
Annals of Diagnostic Pathology
Satellitism, Flow cytometry, Lymphoma, Dual light chain expression, Transmission electron microscopy (TEM), Scanning electron microscopy (SEM)
Platelet satellitism is believed to be an in vitro phenomenon induced at room temperature in ethylenediamine tetraacetic acid–anticoagulated blood. Most reports involve neutrophils; involvement with circulating lymphoma cells are exceedingly rare. Normally, mature B cells exhibit allelic exclusion in which a single class of surface immunoglobulin light chains (either κ or λ ) is expressed. The simultaneous expression of both κ and λ immunoglobulin light chains is rare. Herein, we report the unusual case of a patient with splenic marginal zone lymphoma in which circulating lymphoma cells express dual surface immunoglobulin light chains and exhibit platelet satellitism. In addition to clinical findings, a comprehensive analysis of the peripheral blood including correlated light and electron microscopy as well as flow cytometry are described.
Naomi Montague, Patricia Blackwelder, Husain Ala Al Sayegh, Roberto Ochoa, Ximena Vial, and Gerald E. Byrne. 2013. Platelet Satellitism and Dual Surface Immunoglobulin Light-Chain Expression in Circulating Splenic Marginal Zone Lymphoma Cells .Annals of Diagnostic Pathology , (1) : 117 -122. https://nsuworks.nova.edu/occ_facarticles/443.