Title

Platelet Satellitism and Dual Surface Immunoglobulin Light-Chain Expression in Circulating Splenic Marginal Zone Lymphoma Cells

Document Type

Article

Publication Date

2-1-2013

Publication Title

Annals of Diagnostic Pathology

Keywords

Satellitism, Flow cytometry, Lymphoma, Dual light chain expression, Transmission electron microscopy (TEM), Scanning electron microscopy (SEM)

ISSN

1092-9134

Volume

17

Issue/No.

1

First Page

117

Last Page

122

Abstract

Platelet satellitism is believed to be an in vitro phenomenon induced at room temperature in ethylenediamine tetraacetic acid–anticoagulated blood. Most reports involve neutrophils; involvement with circulating lymphoma cells are exceedingly rare. Normally, mature B cells exhibit allelic exclusion in which a single class of surface immunoglobulin light chains (either κ or λ ) is expressed. The simultaneous expression of both κ and λ immunoglobulin light chains is rare. Herein, we report the unusual case of a patient with splenic marginal zone lymphoma in which circulating lymphoma cells express dual surface immunoglobulin light chains and exhibit platelet satellitism. In addition to clinical findings, a comprehensive analysis of the peripheral blood including correlated light and electron microscopy as well as flow cytometry are described.

Comments

©2013 Elsevier Inc.

DOI

10.1016/j.anndiagpath.2011.06.001

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