Platelet Satellitism and Dual Surface Immunoglobulin Light-Chain Expression in Circulating Splenic Marginal Zone Lymphoma Cells

Authors

Naomi Montague, University of Miami
Patricia Blackwelder, University of MiamiFollow
Husain Ala Al Sayegh, University of MiamiFollow
Roberto Ochoa, University of Miami
Ximena Vial, University of Miami
Gerald E. Byrne, University of Miami

Document Type

Article

Publication Title

Annals of Diagnostic Pathology

ISSN

1092-9134

Publication Date

2-1-2013

Keywords

Satellitism, Flow cytometry, Lymphoma, Dual light chain expression, Transmission electron microscopy (TEM), Scanning electron microscopy (SEM)

Abstract

Platelet satellitism is believed to be an in vitro phenomenon induced at room temperature in ethylenediamine tetraacetic acid–anticoagulated blood. Most reports involve neutrophils; involvement with circulating lymphoma cells are exceedingly rare. Normally, mature B cells exhibit allelic exclusion in which a single class of surface immunoglobulin light chains (either κ or λ ) is expressed. The simultaneous expression of both κ and λ immunoglobulin light chains is rare. Herein, we report the unusual case of a patient with splenic marginal zone lymphoma in which circulating lymphoma cells express dual surface immunoglobulin light chains and exhibit platelet satellitism. In addition to clinical findings, a comprehensive analysis of the peripheral blood including correlated light and electron microscopy as well as flow cytometry are described.

DOI

10.1016/j.anndiagpath.2011.06.001

Volume

17

Issue

1

First Page

117

Last Page

122

Comments

©2013 Elsevier Inc.

NSUWorks Citation

Naomi Montague, Patricia Blackwelder, Husain Ala Al Sayegh, Roberto Ochoa, Ximena Vial, and Gerald E. Byrne. 2013. Platelet Satellitism and Dual Surface Immunoglobulin Light-Chain Expression in Circulating Splenic Marginal Zone Lymphoma Cells .Annals of Diagnostic Pathology , (1) : 117 -122. https://nsuworks.nova.edu/occ_facarticles/443.