Mathematics Faculty Articles
A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries
Document Type
Article
Publication Date
8-23-2012
Publication Title
ACS Combinatorial Science
Keywords
combinatorial libraries, guanidine, harmonic mean, isokinetic ratios, piperazine, positional scanning library, sulfonamide
ISSN
2156-8952
Volume
14
Issue/No.
9
First Page
503
Last Page
512
Abstract
A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.
NSUWorks Citation
Giulianotti, Marc; Debevac, Ginamarie; Santos, Radleigh; Maida, Laura E.; Chen, Wenteng; Ou, Lili; Yu, Yongping; Dooley, Colette T.; and Houghten, Richard A., "A Novel Method for the Determination of Isokinetic Ratios and Its Application in the Synthesis of Two New Positional Scanning Libraries" (2012). Mathematics Faculty Articles. 225.
https://nsuworks.nova.edu/math_facarticles/225
DOI
10.1021/co300060s
Comments
Copyright © 2012 American Chemical Society