Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery

Authors

Radleigh Santos, Torrey Pines Institute for Molecular StudiesFollow
Marc Giulianotti, Torrey Pines Institute for Molecular Studies
Colette T. Dooley, Torrey Pines Institute for Molecular Studies
Clemencia Pinilla, Torrey Pines Institute for Molecular Studies
Jon R. Appel, Torrey Pines Institute for Molecular Studies
Richard A. Houghten, Torrey Pines Institute for Molecular Studies

Document Type

Article

Publication Date

3-11-2011

Publication Title

ACS Combinatorial Science

Keywords

combinatorial libraries, drug discovery, harmonic mean model, mixture activity

ISSN

2156-8952

Volume

13

Issue/No.

3

First Page

337

Last Page

344

Abstract

The use of the harmonic mean model for predicting the activities of a given mixture and its constituents has not previously been explored in the context of combinatorial libraries and drug discovery. Herein, the analyses of historical data confirm the harmonic mean as an accurate predictor of mixture activity. The implications of these results are discussed.

Comments

Copyright © 2011 American Chemical Society

NSUWorks Citation

Santos, Radleigh; Giulianotti, Marc; Dooley, Colette T.; Pinilla, Clemencia; Appel, Jon R.; and Houghten, Richard A., "Use and Implications of the Harmonic Mean Model on Mixtures for Basic Research and Drug Discovery" (2011). Mathematics Faculty Articles. 224.
https://nsuworks.nova.edu/math_facarticles/224

DOI

10.1021/co100065a