Nutrient Deprivation and Growth of Cancer cells Under Normoxia and Hypoxia

Nova Southeastern University, Davie, Florida, USA

Essential Nutrient Amino Acid Such as Methionine is very essential during growth and cell division of normal cells. Normal cell growth and cell divisions are highly regulated process that results in whole body tissues and organs of the human body. In contrast, cancer cells are dysregulated on their growth and cell division process due to any number of mutations that affects the normal growth and developments. This makes it a challenge for universal targeted therapy for cancers. In others words each cancer cell line is developed from various cancer patients behave differently under in vitro conditions, attesting the fact that each cancer is unique and the patient treatment must be customized. Often the cancer that must have developed for example in colon would have metastasized into lung and the cancer cell isolated from the lungs of the patient exhibit features of both tissues in this case colon and lung. The process of metastasis and its maintenance in its new niche requires vascularization and normoxia. Under hypoxic conditions, the process of metastasis is affected and the prolonged sustenance of the cells are affected. We will be looking at the sulfur amino acid deprivation under normoxic and hypoxic conditions to look at various cancer cell survival and growth. Our ultimate goal is to find a common target for various cancer cells for therapy.