TOPOGRAPHIC MAPPING OF MACULA WITH MFERG IN DIFFUSE RETINAL PIGMENT EPITHELIOPATHY

Melnick Auditorium

Introduction. Multifocal electroretinogram (mfERG) is a technique that can topographically map functional changes in the retina. Topographic mapping of macula with mfERG is presented in a unique case of diffuse retinal pigment epitheliopathy (DRPE). Case presentation. A 53 year-old female with DRPE was referred for electrodiagnostic testing to help evaluate vision loss OU lasting for one year. The patient's medical history was significant for multiple sclerosis diagnosed 10 years ago with a past history of immunomodulating therapy. Bestcorrected visual acuity (BVA) was 20/25- OD and 20/30- OS. Funduscopic findings showed yellowish submacular lesion OU, peripheral vitreous cell clumping secondary to an intermediate uveitis OU, and a small area of RPE pigment clumping in the mid-periphery of temporal retina OS. Spectral domain optical coherence tomography (OCT) findings of both maculae showed accumulation of material on the outer retina with subretinal space underneath the thickened retina. MfERG responses showed demarcated attenuation in rings 1 & 2 OU and a small local attenuation in the paracentral rings for inferior temporal retina OS without significant delay. Flash ERG showed normal rod responses and moderate attenuation of cone responses without significant delay OU. Electrooculogram was within normal range OU. Deviation From the Expected. This is a unique presentation of DRPE with both yellow submacular deposition and RPE pigment clumping in the mid-peripheral retina. Discussion. The central macula dysfunction is consistent with the BVA and OCT findings in the patient. Conclusion. MfERG testing provides topographic macula mapping of functional changes in the patient with DRPE. Grants. N/A