Presentation Title
6-Week Clinical Trial Comparing Combination Hygiene and Professional Care
Format
Event
Start Date
10-2-2012 12:00 AM
Abstract
Objective. To compare the safety and effectiveness of combination oral hygiene (brush, paste, rinse, floss) or dental prophylaxis on clinical gingivitis. Methods. Subjects were evaluated to measure gingivitis and randomly assigned to one of two interventions: combination hygiene (CH) or professional care plus routine hygiene (PC). Whole mouth gingivitis was measured at up to 168 sites by a treatment-blinded examiner using a standard index (Loe-Silness Gingivitis Index). The CH group received 0.454% stannous fluoride paste (Crest® Pro-Health Clinical Gum Protection) and a flexible crisscross manual brush (Oral- B® Pro-Health Clinical), 0.07% cetylpryidinium chloride rinse (Crest Pro-Health) and floss (Glide®), while the PC group received a dental prophylaxis plus a regular anticavity paste and manual brush. Subjects were evaluated biweekly over 6-weeks to assess change in gingivitis bleeding sites. Results. Both the CH & PC groups had significant (p < 0.01) improvements in gingivitis bleeding beginning at Week 2 and continuing through Week 6. The CH group exhibited increasing improvement over time, with adjusted bleeding site means of 7.7, 5.2 and 2.2 at Weeks 2, 4 & 6, respectively, while in contrast, the PC group showed disease accumulation, with biweekly bleeding site means of 10.7, 13.2 & 15.5. Groups differed significantly (p < 0.008) beginning at Week 2 and continuing throughout the study. A total of 46 subjects 10 (23 per group) completed the study, and both treatments were well-tolerated. Conclusion. Use of CH resulted in significant (p < 0.01) 80%+ improvements in gingivitis and bleeding relative to PC. Grants. Funded by a grant from the Procter & Gamble Company.
6-Week Clinical Trial Comparing Combination Hygiene and Professional Care
Objective. To compare the safety and effectiveness of combination oral hygiene (brush, paste, rinse, floss) or dental prophylaxis on clinical gingivitis. Methods. Subjects were evaluated to measure gingivitis and randomly assigned to one of two interventions: combination hygiene (CH) or professional care plus routine hygiene (PC). Whole mouth gingivitis was measured at up to 168 sites by a treatment-blinded examiner using a standard index (Loe-Silness Gingivitis Index). The CH group received 0.454% stannous fluoride paste (Crest® Pro-Health Clinical Gum Protection) and a flexible crisscross manual brush (Oral- B® Pro-Health Clinical), 0.07% cetylpryidinium chloride rinse (Crest Pro-Health) and floss (Glide®), while the PC group received a dental prophylaxis plus a regular anticavity paste and manual brush. Subjects were evaluated biweekly over 6-weeks to assess change in gingivitis bleeding sites. Results. Both the CH & PC groups had significant (p < 0.01) improvements in gingivitis bleeding beginning at Week 2 and continuing through Week 6. The CH group exhibited increasing improvement over time, with adjusted bleeding site means of 7.7, 5.2 and 2.2 at Weeks 2, 4 & 6, respectively, while in contrast, the PC group showed disease accumulation, with biweekly bleeding site means of 10.7, 13.2 & 15.5. Groups differed significantly (p < 0.008) beginning at Week 2 and continuing throughout the study. A total of 46 subjects 10 (23 per group) completed the study, and both treatments were well-tolerated. Conclusion. Use of CH resulted in significant (p < 0.01) 80%+ improvements in gingivitis and bleeding relative to PC. Grants. Funded by a grant from the Procter & Gamble Company.