Complications of Durezol Treatment for Anterior Uveitis

Introduction. Durezol (Difluprednate ophthalmic emulsion 0.05%) is a difluorinated derivative of prednisolone with potent antiinflammatory activity. This is a new medication used primarly for inflammation post-surgery. A previous study indicated that only three percent of patients using Durezol developed an increase in intraocular pressure (IOP) of greater than or equal to 10 mm Hg. Case Presentation. This case describes Durezol as a treatment for anterior uveitis unresponsive to prednisolone acetate 1% (Pred Forte) in a 49 year old African American man. Deviation from the expected/Discussion. While no IOP response was noted to prednisolone, the patient experienced a steroid response from Durezol with an IOP increase to 48 mm Hg and subsequent microcystic edema with only 2 week of use. Steroid efficacy and potential side effects of these medications are discussed. Conclusion. All steroids are prescribed with caution due to their potential side effects. Durezol may cause patients to be more at risk for serious side effects. Durezol’s efficacy in relation to Pred Forte is currently under investigation.