Department of Physical Therapy Faculty Articles
Title
Thermal and pH Sensitive Multifunctional Polymer Nanoparticles for Cancer Imaging and Therapy.
ISBN or ISSN
2046-2069
Volume
4
Issue
34
Publication Date / Copyright Date
1-1-2014
First Page
17959
Last Page
17968
DOI Number
10.1039/C4RA01112K
Abstract
In this study, we prepared novel poly (Glycerol malate co-dodecanedioate) (PGMD) NPs containing an imaging/hyperthermia agent (IR820) and a chemotherapeutic agent (doxorubicin, DOX). The PGMD polymer was prepared by thermal condensation. IR820 and DOX loaded PGMD NPs were prepared using the single oil emulsion technique. The size of the NPs measured was around 150 nm. Drug loading efficiency of DOX and IR820 was around 4% and 8%, respectively. An acidic environment (pH=5.0) induced higher DOX release as compared to pH=7.4. DOX release was also enhanced by exposure to laser, which increased the temperature to 42°C. Cytotoxicity of the drug loaded NPs was comparable in MES-SA but was higher in Dx5 cells compared to free drug (p<0.05). The combination of hyperthermia and chemotherapy improved cytotoxicity in both cell lines. The NP formulation significantly improved the plasma half-life of IR820 in mice after tail vein injection.
Disciplines
Medicine and Health Sciences
Keywords
IR820; Chemotherapy; Hyperthermia; multi-functional nano-particles; poly (Glycerol Malate co-dodecanedioate) (PGMD)
NSUWorks Citation
Lei, Tingjun; Manchanda, Romila; Fernandez-Fernandez, Alicia; Huang, Yen-Chih; Wright, Douglas; and McGoron, Anthony J., "Thermal and pH Sensitive Multifunctional Polymer Nanoparticles for Cancer Imaging and Therapy." (2014). Department of Physical Therapy Faculty Articles. 108.
https://nsuworks.nova.edu/hpd_pt_facarticles/108
