NSU-MD Faculty Articles

Title

Hemodynamics of high afterload left heart failure for assist device testing.

ISBN or ISSN

0090-5488

Publication Title

Biomaterials, medical devices, and artificial organs

Volume

10

Issue

4

Publication Date / Copyright Date

1-1-1983

First Page

267

Last Page

279

Publisher

Dekker

Abstract

The hemodynamic responses to increased afterload of the left ventricle were studied in conscious calves during exercise. The calves were chronically instrumented to measure (or derive) heart rate, stroke volume, cardiac output, iliac, superior mesenteric and renal flows and resistances, mean carotid, aortic, right atrial, pulmonary artery, and left atrial pressures, the systemic and pulmonary pressure gradients, and total systemic and total pulmonary resistances. The calves were also instrumented to produce reversible partial constriction of the ascending aorta and common carotid arteries and for cooling of the cervical vagus nerves. The hemodynamic responses to increased afterload were characterized during treadmill exercise at 2 mph. These responses were compared to the hemodynamic responses to bilateral carotid artery occlusion with and without vagal cooling.

Disciplines

Medicine and Health Sciences

Keywords

Animals, Arterial Occlusive Diseases, Assisted Circulation, Carotid Artery Diseases, Cattle, Heart Failure, Hemodynamics, Male, Physical Exertion, Pressoreceptors, Reflex

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