NSU-MD Faculty Articles
Title
Enhancing the efficacy of cancer vaccines in urologic oncology: new directions.
ISBN or ISSN
1759-4812
Publication Title
Nature Reviews Urology
Volume
6
Issue
10
Publication Date / Copyright Date
10-1-2009
First Page
540
Last Page
549
Publisher
Nature Publishing Group
DOI Number
10.1038/nrurol.2009.177
Abstract
Immunotherapeutic interventions have long been utilized in urologic oncology for the treatment of metastatic renal cell or superficial transitional cell carcinoma. Most recently, the first active specific immunotherapeutic approach, a cancer vaccine, has passed the final phase of human testing and its approval by the FDA is pending. However, evidence suggests that the full protective and therapeutic potential of cancer vaccines has not yet been achieved. Through multiple mechanisms, tumors promote conditions in the tumor-bearing host that mitigate or even eliminate the vaccine-induced antitumor response. Restoration of the impaired immune function is, therefore, imperative for achieving optimum vaccine efficacy. Targeted pharmacological interventions are capable of overcoming tumor-mediated immunosuppression, and thereby enable cancer vaccination to reach its full therapeutic potential.
Disciplines
Medicine and Health Sciences
Keywords
Cancer Vaccines, Dinoprostone, Humans, Neoplasms
NSUWorks Citation
Kusmartsev, Sergei and Vieweg, Johannes, "Enhancing the efficacy of cancer vaccines in urologic oncology: new directions." (2009). NSU-MD Faculty Articles. 51.
https://nsuworks.nova.edu/hpd_md_facarticles/51
