NSU-MD Faculty Articles

Title

Vaccines in renal cell carcinoma.

ISBN or ISSN

0093-7754

Publication Title

Seminars in oncology

Volume

33

Issue

5

Publication Date / Copyright Date

10-1-2006

First Page

614

Last Page

624

Publisher

W.B. Saunders Co.

DOI Number

10.1053/j.seminoncol.2006.06.011

Abstract

Considerable progress in our understanding of the molecular and cellular events that promote growth and progression of renal cell carcinoma (RCC) has dramatically improved the prospects of significantly altering the progression and metastatic potential of renal neoplasms. Cancer vaccination, one form of active specific immunotherapy, represents a promising approach which aims to expand the number of T cells capable of reducing/eradicating the tumor mass, and to induce tumor-specific memory T cells that control tumor recurrence. Over the past decade, a number of vaccine strategies have moved from the bench to the bedside and have now become subject to rigorous clinical investigation. This review will examine the current status of vaccine-based therapy for advanced RCC, discuss their mechanisms of action, and provide information on relevant clinical trials. Also discussed are future applications that seek to enhance the vaccine-mediated T-cell response or to make vaccines applicable to broader patient cohorts.

Disciplines

Medicine and Health Sciences

Keywords

Cancer Vaccines, Carcinoma, Renal Cell, Clinical Trials as Topic, Forecasting, Humans, Kidney Neoplasms

Link to Full Text
Peer Reviewed

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