The Institute for Neuro Immune Medicine at Nova Southeastern University strives to advance knowledge and care for people with complex neuro-inflammatory illnesses through the integration of research, clinical care and education.
Current research focus at the Institute for Neuro Immune Medicine (INIM) includes Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI). Investigators, clinicians and educators are committed to applying scientific advances to promote efficiency, enhance patient care and improve clinical utility. This advancement is done through clinical, laboratory, computational and integrative cardiovascular immunological research, all of which are conducted at the INIM by renowned researchers in their respective fields.
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Cytotoxic Lymphocytes
Mary A. Fletcher and Nancy G. Klimas
Like the first edition, the second edition of the Encyclopedia of Stress covers nearly every conceivable aspect and ramification of stress including a wide range of related topics such as neuroimmune interactions, cytokines, enzymatic disorders, effects on the cardiovascular system, immunity and inflammation, and physical illnesses. Over the last decade, scientists have presented convincing research showing that psychological stress increases vulnerability to disease. They now understand more clearly that stress may be the thread tying together illnesses that were previously believed to be unrelated. Bone loss, increased abdominal fat, and damaged memory cells in the hippocampus have been linked to elevated cortisol levels.
Building on the success of the first edition, this completely revised work surveys the vast amount of research generated in the past five years, resulting in a substantial revision with over 30% new material and over 100 new entries. Expanded sections include Animal Studies, Anxiety and Depression, Drugs, Depression, Disasters, and Psychological and Other Therapies.
Also available online via ScienceDirect (2007) - featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com.
* Timely update on the topic of Post-Traumatic Stress Disorder taking into account events such as terrorism and middle east wars
* Includes expanded coverage on anxiety and depression
* Incorporates entries on the advances in our knowledge of immunology, cytokines and cell mediated immunity involved in stress responses and autoimmune diseases such as multiple sclerosis and Type I diabetes -
Psychoneuroimmunology and Fatigue
Nancy G. Klimas, Mary A. Fletcher, K J. Maher, and R. Lawrence
Although fatigue has been actively investigated for more than 100 years, we have progressed little in either its theoretical or practical understanding. Fatigue has been considered to be both a symptom and an illness. Fatigue is a primary reason for patient visits to the physician's office, but it is difficult to measure and offers doctors little important information for diagnosis. Fatigue as a Window to the Brain gathers experts on a wide variety of disorders to consider what the presence of fatigue tells us about how the brain works -- more specifically, to identify the neural mechanisms potentially responsible for fatigue. The book looks at many of the major conditions in which fatigue is observed, with the hope that patterns may emerge that will suggest paths for future research. It will be of interest to neuroscientists, clinical researchers, and physicians and other clinicians.
After discussing the nature of fatigue -- its history and epidemiology and its assessment, measurement, and interpretation -- the book turns to specific conditions associated with fatigue. It considers neurological conditions, including multiple sclerosis and stroke; psychiatric conditions as well as the overall treatment of fatigue in psychiatry; and general medical conditions, including HIV, heart disease, lupus, cancer, and others. The book then offers an overview of treatment approaches. It concludes with a definition of fatigue -- both "primary" and "secondary" -- and suggestions for future study.
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Immunology of Chronic Fatigue Syndrome
Nancy G. Klimas, Mary A. Fletcher, and K. Maher
The "Handbook of Chronic Fatigue Syndrome" provides authoritative coverage of Chronic Fatigue Syndrome (CFS). A leading group of international contributors present up-to-date information and guidance to improve the understanding, proper identification, and treatment of this debilitating disease.
The handbook's comprehensive, multidisciplinary format draws on the medical, as well as mental health-related, aspects of CFS, including: History, diagnosis, and classification Phenomenology Symptomatology Assessment Treatment and intervention Pediatric and community issues Topics covered include complexity of diagnosis, social effects of chronic disorders, and a variety of treatment techniques, including phase-based therapy, cognitive-behavioral therapies, exercise therapy, and nutritional approaches.
An insightful and unique resource, the "Handbook of Chronic Fatigue Syndrome" is an enlightening book for all mental health professionals, including psychologists, social workers, and counselors, as well as medical personnel, such as nurses, physicians, and physical-occupational therapists.
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Stress management interventions and psychosocial predictors of progression in HIV-1 infections
Gail Ironson, Niel Schneiderman, A Laperriere, Nancy G. Klimas, Mary A. Fletcher, and Michael H. Antoni
Psychoneuroimmunology has emerged as a discipline advancing our knowledge of the relationships among psychosocial factors, the central nervous system, the immune system, and disease. The growing volume of evidence suggests that psychological states, including exposure to stressors and the presence of depressive states, may influence health and disease by altering immunologic states. Psychoneuroimmunology, a collaborative work of 50 international experts, expands on the American Psychiatric Association's symposium on this topic to present never-before-compiled scientific research from this evolving field. Maintaining a clinical focus, this book illustrates clinical effects by examining relevant research studies and models including * Psychoneuroimmunological factors involved in specific illnesses such as cervical cancer, breast cancer and HIV/AIDS * The role psychoneuroimmunology plays in carcinogenesis and the progression of established tumors, as well as findings on the progression of cancer that have general clinical relevance* The effects of specific psychotropic medications; the effects of life stressors, bereavement, and and social support; the response to those stressors; and stress management and psychosocial predictors of disease* The impacts of gender-specific factors, diurnal variation, and behavioral genetics on the immune function* The Stressor-Support-Coping model, which integrates existing psychoneuroimmunology findings and lays the groundwork for use in support group intervention This book is a first step toward organizing psychoneuroimmunology findings into coherent theoretical models and concludes with a look at future clinical applications. Complete with charts, references, and a detailed index, it is the most comprehensive source on psychoneuroimmunology.
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Stress and immune function in HIV-1 disease
Mary A. Fletcher, Gail Ironson, K Goodkin, Niel Schneiderman, Nancy G. Klimas, and Michael H. Antoni
Psychological stress is often overlooked by medical doctors as a major factor in physiologically based illness; however, clinical studies show that stress has a vital impact on both the mental and physical well-being of patients. Handbook of Stress Medicine: An Organ System Approach focuses on the relationship between stress and the physiology and pathology of the major organ systems of the body. It suggests that understanding how stress impacts on illnesses can help hold down medical costs through more accurate diagnoses and promote improved preventative care.
Section I offers a general background on stress as it relates to medicine and the difficulties in conducting stress-related research. The primary focus of the text, how stress effects specific organ systems, is examined using scientific and clinical data in Section II. The third section addresses the impact of stress on important medical problems of current interest, such as AIDS, cancer, and substance abuse. It also discusses anxiety disorders. The next section covers topics related to stress, such as stress measurement, stress in the workplace, and the psychodynamics of stress. The final section explores the major pharmacological and non-pharmacological approaches to the treatment of stress and anxiety disorders.
This book will assist physicians, psychologists, nurses, physical therapists, and other health care professionals recognize possible stress-related problems, educate their patients, and develop therapeutic strategies for reducing stress and stress-related illnesses. -
Psychoneuroimmunology: Stress, Mental Disorders and Health
K Goodkin, Paul Shapshak, Mary A. Fletcher, and M. Kumar
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Lymphocyte proliferation
Mary A. Fletcher, D Asthana, J Walling, Alan Friedlander, J. Bryan Page, and R. Urban
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Cryopreservation of peripheral blood mononuclear cells
Roberto Patarca, K J. Maher, K Goodkin, and Mary A. Fletcher
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Psychoneuroimmunology and HIV/AIDS
Niel Schneiderman, Gail Ironson, Susan Lutgendorf, Barry E. Hurwitz, Nancy G. Klimas, A Laperriere, Mary A. Fletcher, and Michael H. Antoni
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Psychosocial Stressors, herpes virus reactivation and HIV infection
B A. Esterling, Susan Lutgendorf, Mary A. Fletcher, Niel Schneiderman, and Michael H. Antoni
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The psychoneuroimmunological impact of bereavement and a support group in HIV-1 infection
K Goodkin, N T. Blaney, R S. Tuttle, Jeffrey L. Lehman, Mary A. Fletcher, Marianna K. Baum, M. Kumar, R. Mahmood, J. Burkhalter, B. Leeds, and J. Feaster
Psychoneuroimmunology has emerged as a discipline advancing our knowledge of the relationships among psychosocial factors, the central nervous system, the immune system, and disease. The growing volume of evidence suggests that psychological states, including exposure to stressors and the presence of depressive states, may influence health and disease by altering immunologic states. Psychoneuroimmunology, a collaborative work of 50 international experts, expands on the American Psychiatric Association's symposium on this topic to present never-before-compiled scientific research from this evolving field. Maintaining a clinical focus, this book illustrates clinical effects by examining relevant research studies and models including * Psychoneuroimmunological factors involved in specific illnesses such as cervical cancer, breast cancer and HIV/AIDS * The role psychoneuroimmunology plays in carcinogenesis and the progression of established tumors, as well as findings on the progression of cancer that have general clinical relevance* The effects of specific psychotropic medications; the effects of life stressors, bereavement, and and social support; the response to those stressors; and stress management and psychosocial predictors of disease* The impacts of gender-specific factors, diurnal variation, and behavioral genetics on the immune function* The Stressor-Support-Coping model, which integrates existing psychoneuroimmunology findings and lays the groundwork for use in support group intervention This book is a first step toward organizing psychoneuroimmunology findings into coherent theoretical models and concludes with a look at future clinical applications. Complete with charts, references, and a detailed index, it is the most comprehensive source on psychoneuroimmunology.
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Psychosocial interventions and quality of life changes across the HIV spectrum
Susan Lutgendorf, Niel Schneiderman, Gail Ironson, Mary A. Fletcher, and Michael H. Antoni
The number of, and interest in, quality of life studies has grown dramatically in the last decade. On an ever increasing basis, patients, clinicians, researchers, and health policy regulators are considering quality of life in assessing treatment alternatives. Unfortunately, most discussions of quality of life are narrow in scope -- applying to only one disease group. This unique book represents the concerted effort of experts in academia, federal government health care regulators, and pharmaceutical industry representatives to define the promise and the problems associated with quality of life studies. The issues covered range from cross cutting ones to those that are specific to particular illnesses.
Because quality of life takes into consideration such domains as mood, vocation, family, sexual functioning, social participation, and costs, this book will serve as an invaluable companion to readers with an interest in behavioral medicine research. -
HIV-1, Immunity and Behavior
Niel Schneiderman, Gail Ironson, Nancy G. Klimas, A LaPerriere, B A. Esterling, Mary A. Fletcher, Michael H. Antoni, and M. Kumar
In 1964, George Solomon coined the term psychoneuroimmunology. In the intervening 30 years, this term has emerged into a dynamic field of study which investigates the unique interactions between the nervous, endocrine, and immune systems. The Handbook of Human Stress and Immunity is a comprehensive reference for this dynamic new field. Focusing on how stressors impact the central nervous system and the resulting changes in immune responses, the Handbook is the first to describehow stress specifically affects human immune systems. It discusses how stress generally makes people more susceptible to infection, how personal support systems can counteract the physiological effects of stress, and how stress, or lack of stress, affects the aging process. Chapters are authored by the leading names in the field and cover such diseases as autoimmune disease, viral pathogenesis, herpes, HIV, and AIDS.
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Immunologic Consequences of Treatment for Drug Abuse
Mary A. Fletcher, Nancy G. Klimas, and R. Morgan
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The Physiologic Perspective: Immune System
Mary A. Fletcher and M. S. Nash
Overview. Issues of Aging with Spinal Cord Injury: Robert Menter. The Research Perspective. Research into the Aging Process: Susan Charlifue; Learning from Recent Empirical Investigations: Gale Whiteneck. The Physiologic Perspective. Aging Skin, Pressure Ulcerations, and Spinal Cord Injury: Gary Yarkony; The Musculoskeletal System: Robert Waters et al.; The Cardiovascular System: Kristjan Ragnarsson; The Respiratory System: Conal Wilmot and Karyl Hall; The Genitourinary System: Indira Lanig; The Gastrointestinal System: Bard Cosman et al.; The Nervous System: Daniel Lammertse; The Endocrine System: William Bauman; The Immune System: Mark Nash and Mary Ann Fletcher; Clinical Issues Involving Multiple Organ Systems: Deborah Short. The Psychosocial Perspective. Changing Care Needs: Frederick Maynard; Psychological Adaptation: Lester Butt and Melinda Fitting; Changing Attitudes Toward Life: Gale Whiteneck. The Spinal Cord Injury Survivor's Perspective. What Price Independence?: Barry Corbet; Becoming Successful Health Care Consumers: Glenn Reynolds; Personal Perspectives: Kenneth Gerhart. The Societal Perspective. Societal Responses to Long-Term Disability: Michael Oliver; Political Responses to Long-Term Disability: Margaret Nosek; Financing Health and Personal Care: Gerben DeJong et al.; Ethical Issues and the Care of the Elderly Disabled: Giles Scofield; Aging with a Disability: The Spiritual Component: Harold Wilke. The Provider's Perspective. Changes in Health Care: A British Perspective: Gerry Zarb; Changing Rehabilitation Philosophy for Aging: Robert Menter; Changing Educational Strategies: Kathie Seedroff and Kevin McVeigh; Changing the Adaptive Environment: Kenneth Gerhart; A Model of Lifetime Services: Bonnie Sims et al.. The Future Perspective. Where Do We Go From Here?: Gale Whiteneck and Robert Menter.
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Clinical Observations Regarding Use of an Anti-Depressant, Fluoxetine. in Chronic Fatigue Syndrome
Nancy G. Klimas, F van Riel, Mary A. Fletcher, and R. Morgan
The latest research in neurobiology and in biological psychiatry has led to the discovery of many interactions between mood states and alterations in brain neurochemistry, neuroendocrinology, and brain imaging. Chronic Fatigue and Related Immune Deficiency Syndromes presents a state-of-the-art synthesis of research into disorders of chronic fatigue. It examines the relationship of chronic fatigue and related immune deficiency syndromes to major biological depression and reviews how they are alike and how they differ in etiology, psychopathology, neuroendocrinology, neurochemistry, and treatment. The chapters on treatment review all the varying approaches currently being used (along with the theories on which they are based) to set the scene for future developments in antivirals and antidepressants. This comprehensive yet concise text presents what is known on chronic fatigue syndrome from the vantage point of experts in the fields of immunology, virology, and neuroendocrinology.
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Immunological Correlates of Chronic Fatigue Syndrome
Roberto Patarca, Nancy G. Klimas, and Mary A. Fletcher
The latest research in neurobiology and in biological psychiatry has led to the discovery of many interactions between mood states and alterations in brain neurochemistry, neuroendocrinology, and brain imaging. Chronic Fatigue and Related Immune Deficiency Syndromes presents a state-of-the-art synthesis of research into disorders of chronic fatigue. It examines the relationship of chronic fatigue and related immune deficiency syndromes to major biological depression and reviews how they are alike and how they differ in etiology, psychopathology, neuroendocrinology, neurochemistry, and treatment. The chapters on treatment review all the varying approaches currently being used (along with the theories on which they are based) to set the scene for future developments in antivirals and antidepressants. This comprehensive yet concise text presents what is known on chronic fatigue syndrome from the vantage point of experts in the fields of immunology, virology, and neuroendocrinology.
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Endocrine responses, immunity and HIV spectrum disease
Niel Schneiderman, Mary A. Fletcher, Nancy G. Klimas, A LaPerriere, Michael H. Antoni, G. Tronson, and M. Kumar
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Chronic Fatigue Syndrome and Psychoneuroimmunology
Nancy G. Klimas, Flavia van Riel, C Millon, Mary A. Fletcher, R. Morgan, and F. Salvato
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Exercise and Health Maintenance in AIDS
A Laperriere, Mary A. Fletcher, Niel Schneiderman, and Michael H. Antoni
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Psychoneuroimmunology and stress responses in HIV 1 seropositive and at risk gay men
Niel Schneiderman, A Laperriere, Mary A. Fletcher, Michael H. Antoni, and L. Bourguinon
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Mothers with AIDS
Niel Schneiderman, A Laperriere, M J. O'Sullivan, Mary A. Fletcher, and Michael H. Antoni
In this nation, in this decade, there is only one way to deal with an individual who is sick-with dignity, with compassion, care and confidentiality, and without discrimi nation. Statement made by President George Bush at the National Business Leadership Conference This book is about the care of sick human beings. It is about the heroic struggle of individuals with AIDS. It is about their daily coping in the workplace and at home; about economic problems, the loss of friendship and family support, and physical and emotional pain. But it is also about empowering them to deal with their disease, viewing them not as victims but as warriors, vital and active par ticipants in their battle against AIDS. This book is also about the social context in which HIV-infected persons and people with AIDS live. It is about how we must learn to deal with sickness in more compassionate and humanitarian ways and what we yet need to learn. It touches on the health care system that confronts those who are ill, on programs of prevention and education, and on the personal implications of broader national and local policies.
