Health Sciences Program Student Theses, Dissertations and Capstones

Document Type

Dissertation - NSU Access Only

Degree Name

Doctor of Philosophy (PhD) in Health Science

Copyright Statement

All rights reserved. This publication is intended for use solely by faculty, students, and staff of Nova Southeastern University. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, now known or later developed, including but not limited to photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author or the publisher.

Department

College of Health Care Sciences – Health Science Department

First Advisor

Kamilah Thomas-Purcell

Date of original Performance / Presentation

January 2023

Publication Date / Copyright Date

1-1-2023

Abstract

Ovarian cancer is a leading cause of female-related cancer diagnoses and continues to have five-year survival rates under 50%. Risk factors for ovarian cancer are limited and largely unmodifiable. However, evidence has suggested inflammation as a potential mechanism of ovarian cancer development. One possible cause of deleterious inflammation may be through reduced kidney function increasing systemic inflammation that causes damage to ovarian and fallopian epithelial tissue, leading to tumor development. Participants from the U.K. Biobank, a prospective cohort with over 230,000 women and 1,120 incident ovarian cancer cases, were included and assays were conducted from blood and urine samples to measure markers of kidney function. Cox proportional hazard models were used to evaluate the association of estimated glomerular filtration rate, creatinine, cystatin C, microalbumin, potassium, sodium, urea, and uric acid with ovarian cancer risk. The interaction between C-reactive protein (CRP) and body mass index (BMI) with the relationship of kidney function and ovarian cancer risk was assessed. No clear associations were observed overall or by histological subtype. Although there was no significant interaction, the risk of ovarian cancer was higher among women with poor kidney function and increased CRP or BMI compared to women with better kidney function and lower CRP or BMI. This study provided the first evaluation of ovarian cancer risk with markers of kidney function and the suggestive findings with CRP and BMI indicate systemic inflammation and poor kidney function may increase ovarian cancer risk. Future work is needed to evaluate these associations among women with declining kidney function.

Disciplines

Medicine and Health Sciences

Keywords

biomarkers; eGFR; inflammation; kidney function; ovarian cancer; risk

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