Health Sciences Program Student Theses, Dissertations and Capstones

Document Type

Dissertation - NSU Access Only

Degree Name

Doctor of Philosophy (PhD) in Health Science

Copyright Statement

All rights reserved. This publication is intended for use solely by faculty, students, and staff of Nova Southeastern University. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, now known or later developed, including but not limited to photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author or the publisher.

Department

College of Health Care Sciences – Health Science Department

First Advisor

Elliot Sklar

Date of original Performance / Presentation

January 2023

Publication Date / Copyright Date

1-1-2023

Abstract

Background: Multidrug-resistant organisms (MDROs) are a common cause of healthcare-associated infections, particularly central line–associated bloodstream infections (CLABSIs). The purpose of the study was to determine the relationship between the risk of a patient who had a CLABSI event with an MDRO and 90-day mortality and readmission after discharge and the role of age in these relationships. Methods: A retrospective analysis of patient data from AdventHealth Orlando occurred for patients who had a CLABSI between January 1, 2018, and December 31, 2019. Descriptive statistics were used to characterize the sample, with logistic regression analyses performed to identify risk factors for mortality, readmission, and age. Results: Logistic regression analyses found that there was not a significant difference in mortality (OR = 0.67, p = .550) or readmission (OR = 1.79, p = .215) events within 90 days in patients who had an MDRO as a causative pathogen of their CLABSI. Examining age as a covariate for readmission or mortality outcome showed a 2.66% decreased readmission risk for every 1-year increase in patient age (p = .019). Conclusion: Decreased readmission risk from an MDRO associated with increasing age may result from increased patient–provider interactions as patients age. The study’s results may be due to the overall younger population in this dataset (mean age = 56.8) than in prior research and the small number of patients over 65 (n = 49). Additional research with a larger study sample is recommended.

Disciplines

Medicine and Health Sciences

Keywords

CLABSI; healthcare associated infection; mortality; multidrug resistant organism; readmission

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