Health Sciences Program Student Theses, Dissertations and Capstones
Document Type
Dissertation
Degree Name
Doctor of Philosophy (PhD) in Health Science
Copyright Statement
All rights reserved. This publication is intended for use solely by faculty, students, and staff of Nova Southeastern University. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, now known or later developed, including but not limited to photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author or the publisher.
Department
College of Health Care Sciences – Health Science Department
First Advisor
Elizabeth Swann
Publication Date / Copyright Date
2018
Publisher
Nova Southeastern University
NSUWorks Citation
Datis Kharrazian. 2018. Association between Immunological Reactivity with Tetrabromobisphenol-A and Autoimmune Target Sites of the Nervous System. Doctoral dissertation. Nova Southeastern University. Retrieved from NSUWorks, College of Health Care Sciences – Health Science Department. (12)
https://nsuworks.nova.edu/hpd_hs_stuetd/12.
Abstract
Tetrabromobisphenol-A (TBBPA) is the most widely used flame retardant. Flame retardants are sprayed on furniture, mattress beds, children’s pajamas, car seats, upholstery, carpets, and rugs in the United States. Chemical immune reactivity may play a role in the epidemic of autoimmune disease. The goal of this research is to investigate whether any correlation exists between immunological reactivity to TBBPA, a key chemical used in most flame retardants, and neurological autoimmune target sites that are associated with neurological autoimmune diseases with a diverse and specific list of antibodies that include myelin basic protein, myelin-associated glycoprotein, alpha-synuclein, aquaporin receptors, and S100B antibodies with human serum samples. The outcomes of this research can be used to support the development of safety regulations and for identifying potential health concerns for current mandatory flame-retardant legislation. Additionally, this research may support the decisions made in respect of those suffering from neurological autoimmune diseases, as to whether removing flame retardant chemicals is a factor for consideration.
Disciplines
Medicine and Health Sciences
Keywords
Health and environmental sciences, Alpha-synuclein, Autoimmunity, Myelin basic protein, Myelin oligodenrocyte protein, S100B, Tetrabromobisphenol-A