Department of Health Sciences Faculty Articles
PubMed Identifier
8623760
Blast-like Cells in the CSF of Young Infants: Further Characterization of Clinical Setting, Morphology, and Origin
Document Type
Article
Publication Date
1996
Keywords
bone marrow, infant, leukemia, centrifugation
Abstract
Blast-like cells in the cerebrospinal fluid (CSF) of neonates have been identified and previously suggested to be of germinal matrix origin. Twelve additional CSF specimens with blast-like cells collected at the University of Texas Medical Branch, Galveston, between 1985-1992 were analyzed. The cytological features of the blast-like cells as well as their associated clinical setting were further characterized by the authors. All patients in the study were young infants with hydrocephalus and nearly all underwent placement of a ventriculoperitoneal (VP) shunt at the time the CSF specimen was collected. In addition, a cytologic preparation of germinal matrix cells obtained from an autopsy specimen was analyzed, which closely resembled the blast-like cells. These data provide additional evidence that blast-like cells originate from the germinal matrix.
Volume
105
First Page
544
Last Page
547
Disciplines
Medicine and Health Sciences
NSUWorks Citation
Jaffey, Pamela; Varma, Sudhir K.; DeMay, Richard M.; McLucas, Eddye; and Campbell, Gerald A., "Blast-like Cells in the CSF of Young Infants: Further Characterization of Clinical Setting, Morphology, and Origin" (1996). Department of Health Sciences Faculty Articles. 178.
https://nsuworks.nova.edu/hpd_hs_facarticles/178