Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors

Authors

Mark D. Ericson, University of Minnesota
Anamika Singh, University of Minnesota; University of Florida
Srinivasa R. Tala, University of Minnesota; University of Florida
Erica M. Haslach, University of Florida
Marvin L. Dirain, University of Florida
Jay W. Schaub, University of Florida
Viktor Flores, University of Florida
Natalie Eick, University of Florida
Cody J. Lensing, University of Minnesota
Katie T. Freeman, University of Minnesota
Branden A. Smeester, University of Minnesota
Danielle N. Adank, University of Minnesota
Stacey L. Wilber, University of Minnesota
Robert Speth, Nova Southeastern UniversityFollow
Carrie Haskell-Luevano, University of Florida

Document Type

Article

Publication Date

4-26-2018

Publication Title

Journal of Medicinal Chemistry

ISSN

0022-2623

Volume

61

Issue/No.

8

First Page

3738

Last Page

3744

Abstract

β-Defensin 3 (BD3) was identified as a ligand for the melanocortin receptors (MCRs) in 2007, although the pharmacology activity of BD3 has not been clearly elucidated. Herein, it is demonstrated that human BD3 and mouse BD3 are full micromolar agonists at the MCRs. Furthermore, mouse β-defensin 1 (BD1) and human BD1 are also MCR micromolar agonists. This work identifies BD1 as an endogenous MCR ligand and clarifies the controversial role of BD3 as a micromolar agonist.

NSUWorks Citation

Ericson, Mark D.; Singh, Anamika; Tala, Srinivasa R.; Haslach, Erica M.; Dirain, Marvin L.; Schaub, Jay W.; Flores, Viktor; Eick, Natalie; Lensing, Cody J.; Freeman, Katie T.; Smeester, Branden A.; Adank, Danielle N.; Wilber, Stacey L.; Speth, Robert; and Haskell-Luevano, Carrie, "Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors" (2018). HPD Articles. 93.
https://nsuworks.nova.edu/hpd_facarticles/93

ORCID ID

0000-0002-6434-2151

DOI

10.1021/acs.jmedchem.8b00251

Copyright

Copyright © 2018 American Chemical Society