Document Type
Article
Publication Date
5-12-2023
Publication Title
Current Oncology
Keywords
Humans, ErbB Receptors, Retrospective Studies, Carcinoma, Non-Small-Cell Lung, Glioblastoma, Venous Thromboembolism, Lung Neoplasms, In Situ Hybridization, Fluorescence, Prognosis
ISSN
1718-7729
Volume
30
Issue/No.
5
First Page
4946
Last Page
4956
Abstract
Introduction: Glioblastoma (GBM) patients have a 20-30 incidence of venous thromboembolic events. EGFR is a widely used prognostic marker for many cancers. Recent lung cancer studies have described relationships between EGFR amplification and an increased incidence of thromboembolic complications. We aim to explore this relationship in glioblastoma patients. Methods: Two hundred ninety-three consecutive patients with IDH wild-type GBM were included in the analysis. The amplification status of EGFR was measured using fluorescence in situ hybridization (FISH). Centromere 7 (CEP7) expression was recorded to calculate the EGFR-to-CEP7 ratio. All data were collected retrospectively through chart review. Molecular data were obtained through the surgical pathology report at the time of biopsy. Results: There were 112 subjects who were EGFR-amplified (38.2%) and 181 who were non-amplified (61.8%). EGFR amplification status was not significantly correlated with VTE risk overall (p = 0.2001). There was no statistically significant association between VTE and EGFR status after controlling for Bevacizumab therapy (p = 0.1626). EGFR non-amplified status was associated with an increased VTE risk in subjects greater than 60 years of age (p = 0.048). Conclusions: There was no significant difference in occurrence of VTE in patients with glioblastoma, regardless of EGFR amplification status. Patients older than 60 years of age with EGFR amplification experienced a lower rate of VTE, contrary to some reports on non-small-cell lung cancer linking EGFR amplification to VTE risk.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
NSUWorks Citation
Kaye, Brandon Y.; Ali, Assad; Correa Bastianon Santiago, Raphael Augusto; Ibrahim, Bilal; Isidor, Julio; Awad, Hany; Sabahi, Mohammadmahdi; Obrzut, Michal; Adada, Badih; Ranjan, Surabhi; and Borghei-Razavi, Hamid, "The Role of EGFR Amplification in Deep Venous Thrombosis Occurrence in IDH Wild-Type Glioblastoma." (2023). HPD Articles. 487.
https://nsuworks.nova.edu/hpd_facarticles/487
ORCID ID
0000-0002-2047-3396, 0000-0003-3690-8275, 0000-0002-1235-1233,
DOI
10.3390/curroncol30050373
Copyright
© 2023 by the authors.
