Circular RNAs as novel biomarkers in glomerular diseases
Document Type
Article
Publication Date
5-16-2023
Publication Title
Archives of Physiology and Biochemistry
Keywords
circular RNAs, glomerulopathy, long non-coding RNAs, glomerulus, kidney
ISSN
1744-4160
Abstract
Circular RNAs (circRNAs) regulate gene expression and biological procedures by controlling target genes or downstream pathways by sponging their related miRNA (s). Three types of circRNAs have been identified; exonic circRNAs (ecircRNAs), intronic RNAs (ciRNAs), and exon-intron circRNAs (ElciRNAs). It is clarified that altered levels of circRNAs have dynamic pathological and physiological functions in kidney diseases. Evidence suggests that circRNAs can be considered novel diagnostic biomarkers and therapeutic targets for renal diseases. Glomerulonephritis (GN) is a general term used to refer to a wide range of glomerular diseases. GN is an important cause of chronic kidney diseases. Here, we review the biogenesis of circRNAs, and their molecular and physiological functions in the kidney. Moreover, the dysregulated expression of circRNAs and their biological functions are discussed in primary and secondary glomerulonephritis. Moreover, diagnostic and therapeutic values of circRNAs in distinguishing or treating different types of GN are highlighted.
NSUWorks Citation
Hejazian, Seyyedeh Mina; Rahbar Saadat, Yalda; Hosseiniyan Khatibi, Seyed Mahdi; Farnood, Farahnoosh; Farzamikia, Negin; Hejazian, Seyyed Sina; Batoumchi, Sepideh; Shoja, Mohammadali M.; Ardalan, Mohammadreza; and Zununi Vahed, Sepideh, "Circular RNAs as novel biomarkers in glomerular diseases" (2023). HPD Articles. 438.
https://nsuworks.nova.edu/hpd_facarticles/438
DOI
10.1080/13813455.2023.2212328
Copyright
© 2023 informa UK limited, trading as taylor & francis group
Comments
This study was financially supported by Tabriz University of Medical Sciences, Tabriz, Iran (Grant number, #71588).