Document Type
Article
Publication Date
4-25-2023
Publication Title
Journal of the International Society of Sports Nutrition
Keywords
Ergogenic aids, supplements, aerobic, anaerobic, exercise
ISSN
1550-2783
Volume
20
Issue/No.
1
First Page
2204071
Abstract
Creatine supplementation is an effective ergogenic aid to augment resistance training and improve intense, short duration, intermittent performance. The effects on endurance performance are less known. The purpose of this brief narrative review is to discuss the potential mechanisms of how creatine can affect endurance performance, defined as large muscle mass activities that are cyclical in nature and are >~3 min in duration, and to highlight specific nuances within the literature. Mechanistically, creatine supplementation elevates skeletal muscle phosphocreatine (PCr) stores facilitating a greater capacity to rapidly resynthesize ATP and buffer hydrogen ion accumulation. When co-ingested with carbohydrates, creatine enhances glycogen resynthesis and content, an important fuel to support high-intensity aerobic exercise. In addition, creatine lowers inflammation and oxidative stress and has the potential to increase mitochondrial biogenesis. In contrast, creatine supplementation increases body mass, which may offset the potential positive effects, particularly in weight-bearing activities. Overall, creatine supplementation increases time to exhaustion during high-intensity endurance activities, likely due to increasing anaerobic work capacity. In terms of time trial performances, results are mixed; however, creatine supplementation appears to be more effective at improving performances that require multiple surges in intensity and/or during end spurts, which are often key race-defining moments. Given creatines ability to enhance anaerobic work capacity and performance through repeated surges in intensity, creatine supplementation may be beneficial for sports, such as cross-country skiing, mountain biking, cycling, triathlon, and for short-duration events where end-spurts are critical for performance, such as rowing, kayaking, and track cycling.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
NSUWorks Citation
Forbes, Scott C.; Candow, Darren G.; Falk Neto, Joao Henrique; Kennedy, Michael D.; Forbes, Jennifer L.; Machado, Marco; Bustillo, Erik; Gomez-Lopez, Jose; Zapata, Andres; and Antonio, Jose, "Creatine supplementation and endurance performance: surges and sprints to win the race." (2023). HPD Articles. 417.
https://nsuworks.nova.edu/hpd_facarticles/417
ORCID ID
DOI
10.1080/15502783.2023.2204071
Copyright
© 2023 The Author(s).
Comments
Disclosure statement: JA is Chief Executive Officer and EB is the vice president of the ISSN, an academic nonprofit that receives support and/or sponsorship from companies that manufacture and/or sell creatine or creatine-containing products. EB has an affiliate link with Thorne that sells creatine. DGC has received research grants and performed industry sponsored research involving creatine supplementation, received creatine donation for scientific studies and travel support for presentations involving creatine supplementation at scientific conferences. In addition, DGC serves on the Scientific Advisory Board for Alzchem (a company which manufactures creatine) and the editorial review board for the Journal of the International Society of Sports Nutrition and is a sports science advisor to the ISSN. Furthermore, DGC has previously served as the Chief Scientific Officer for a company that sells creatine products. SCF has served as a scientific advisor for a company that sells creatine products. JGL owns a company that sells creatine products. All other authors declare no conflicts of interests.