Document Type
Article
Publication Date
8-22-2023
Publication Title
Cureus
Keywords
aggrastat, cranial surgery, aspirin, plavix, intraoperative/postoperative anticoagulation
ISSN
2168-8184
Volume
15
Issue/No.
8
First Page
e43899
Abstract
Anticoagulation therapy is critical to avoiding thrombotic events in patients following cranial surgery. Although Aspirin, Plavix, and Aggrastat are used as anticoagulants for this purpose, there is no consensus on which agent is the most effective and safe. In this comparative study, we analyze the current evidence on the efficacy and safety of these three anticoagulants in the context of cranial surgeries. This review focuses on the advantages and disadvantages of each anticoagulant, such as its pharmacokinetics, indications, contraindications, and possible consequences. The outcomes of this study will help physicians choose the best anticoagulant for their patients based on individual patient characteristics and the kind of cranial procedure. Aggrastat's potential to be included as a recommended anticoagulant for cranial procedures warrants further study.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
NSUWorks Citation
Kumar, Harendra; Boini, Aishwarya; Tshibangu, Mpuekela; Ghosh, Bikona; Shaheen, Fatima; Joseph, Andrew M; Cazzaniga, Juliana; Karas, Monica; Jara Silva, Cesar E; Quinonez, Jonathan; and Ruxmohan, Samir, "Anticoagulation Options for Cranial Procedures: A Comparative Review of Aspirin, Plavix, and Aggrastat." (2023). HPD Articles. 281.
https://nsuworks.nova.edu/hpd_facarticles/281
ORCID ID
DOI
10.7759/cureus.43899
Copyright
© Copyright 2023 Kumar et al.
Comments
This comparative review is considered a multi-institutional research endeavor that was pursued under the guidance and tutelage of the two lead physicians on this research, JQ and SR. In addition to JQ and SR, HK, AB, MT, BG, FS, AMJ, JC, MK, and CEJS each substantially contributed to the genesis and design of the project and assisted in the acquisition, analysis, and interpretation of articles utilized in this comparative review, which required data collection from a variety of search engines such as PubMed, OVID Medline, and Cochrane. Each and every author actively participated in the writing of multiple iterations until finally concocting a final draft to be reviewed and approved. JQ is a resident at Larkin Hospital, and SR served as senior author. Furthermore, all authors read and approved the final manuscript.