Document Type
Article
Publication Date
7-25-2023
Publication Title
Gels
Keywords
curcumin gel formulations, transdermal delivery, periodontal therapy, ocular inserts, gastrointestinal bioavailability
ISSN
2310-2861
Volume
9
Issue/No.
8
First Page
596
Abstract
Curcumin, a potent active compound found in turmeric and Curcuma xanthorrhiza oil, possesses a wide range of therapeutic properties, including antibacterial, anti-inflammatory, antioxidant, and wound healing activities. However, its clinical effectiveness is hindered by its low bioavailability and rapid elimination from the body. To overcome these limitations, researchers have explored innovative delivery systems for curcumin. Some promising approaches include solid lipid nanoparticles, nanomicelle gels, and transdermal formulations for topical drug delivery. In the field of dentistry, curcumin gels have shown effectiveness against oral disorders and periodontal diseases. Moreover, Pickering emulsions and floating in situ gelling systems have been developed to target gastrointestinal health. Furthermore, curcumin-based systems have demonstrated potential in wound healing and ocular medicine. In addition to its therapeutic applications, curcumin also finds use as a food dye, contraception aid, corrosion-resistant coating, and environmentally friendly stain. This paper primarily focuses on the development of gel compositions of curcumin to address the challenges associated with its clinical use.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
NSUWorks Citation
Omidian, Hossein; Wilson, Renae L.; and Chowdhury, Sumana Dey, "Enhancing Therapeutic Efficacy of Curcumin: Advances in Delivery Systems and Clinical Applications." (2023). HPD Articles. 263.
https://nsuworks.nova.edu/hpd_facarticles/263
ORCID ID
DOI
10.3390/gels9080596
Copyright
© 2023 by the authors.
Comments
Conflicts of Interest: The authors partly used OpenAI’s large-scale language-generation model. The authors reviewed, revised, and edited the document for accuracy and take full responsibility for the content of this publication. The authors used Bing AI image creator to draw the graphical abstract.