A multicenter virome analysis of blood, feces, and saliva in myalgic encephalomyelitis/chronic fatigue syndrome.
Journal of Medical Virology
chronic fatigue syndrome, ME/CFS, myalgic encephalomyelitis, sequencing, virome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is estimated to affect 0.4%-2.5% of the global population. Most cases are unexplained; however, some patients describe an antecedent viral infection or response to antiviral medications. We report here a multicenter study for the presence of viral nucleic acid in blood, feces, and saliva of patients with ME/CFS using polymerase chain reaction and high-throughput sequencing. We found no consistent group-specific differences other than a lower prevalence of anelloviruses in cases compared to healthy controls. Our findings suggest that future investigations into viral infections in ME/CFS should focus on adaptive immune responses rather than surveillance for viral gene products.
Briese, Thomas; Tokarz, Rafal; Bateman, Lucinda; Che, Xiaoyu; Guo, Cheng; Jain, Komal; Kapoor, Vishal; Levine, Susan; Hornig, Mady; Oleynik, Alexandra; Quan, Phenix-Lan; Wong, Wai H.; Williams, Brent L.; Vernon, Suzanne D.; Klimas, Nancy G.; Peterson, Daniel L.; Montoya, Jose G.; and Lipkin, Walter Ian, "A multicenter virome analysis of blood, feces, and saliva in myalgic encephalomyelitis/chronic fatigue syndrome." (2023). HPD Articles. 260.
© 2023 Wiley Periodicals LLC.