Dietary supplementation with resveratrol protects against striatal dopaminergic deficits produced by in utero LPS exposure

Document Type

Article

Publication Date

7-21-2014

Publication Title

Brain Research

Keywords

Dopamine, Lipopolysaccharide, Postnatal development, Resveratrol, Striatum, Tyrosine hydroxylase

ISSN

0006-8993

Volume

1573

First Page

37

Last Page

43

Abstract

The purpose of this study was to determine the effect of dietary supplementation with the anti-inflammatory compound resveratrol in pregnant dams on lipopolysaccharide (LPS)-induced dopaminergic deficits in pups exposed to LPS in utero. Gravid female rats were fed with a resveratrol-enriched diet during gestational days 3-22.5 (E3-E22.5) and received an intraperitoneal (i.p.) injection of 1mg/kg LPS at E10.5. The striata were isolated from the pups at postnatal days 10 (P10) and P21. LPS-induced dopaminergic deficits were noted at P21, but not P10. These DA deficits at P21 were exhibited by a loss of DA and DA metabolite [3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)] levels and tyrosine hydroxylase (TH) expression in the striatum. The LPS-induced loss of DA, DA metabolites, and TH expression were attenuated in the striata of pups from the dams fed with the resveratrol-supplemented diet. These data suggest that a resveratrol-supplemented diet may restore homeostasis of the striatal DA neuronal system following disruption by LPS.

ORCID ID

0000-0003-4970-9857

DOI

10.1016/j.brainres.2014.05.028

Link to Full Text
Peer Reviewed

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