Human Cytomegalovirus (CMV) Infection Associated With Decreased Risk of Bronchogenic Carcinoma: Understanding How a Previous CMV Infection Leads to an Enhanced Immune Response Against Malignancy.

Authors

Selena Rashid, Nova Southeastern University, Holy Cross HealthFollow
Amalia Ardeljan, Holy Cross Health
Lexi R. Frankel, Nova Southeastern University, Holy Cross HealthFollow
Matthew Cardeiro, Nova Southeastern University, Holy Cross HealthFollow
Enoch Kim, Nova Southeastern University, Holy Cross HealthFollow
Brittany M. Nagel, Nova Southeastern University, Holy Cross HealthFollow
Kazuaki Takabe, Roswell Park Comprehensive Cancer Center, The State University of New York
Omar Rashid, Nova Southeastern University, Holy Cross Health, University of Miami, Massachusetts General Hospital, Broward Health, Topline MD Alliance, Memorial Healthcare, Delray Medical Center

Document Type

Article

Publication Date

4-7-2023

Publication Title

Cureus

Keywords

oncology, microbiology, immunology, bronchogenic carcinoma, malignancy

ISSN

2168-8184

Volume

15

Issue/No.

4

First Page

e37265

Abstract

INTRODUCTION:  Cytomegalovirus (CMV) causes a long-lasting, asymptomatic infection that reportedly has both advantageous and deleterious effects on tumor progression. The purpose of this study was to evaluate the correlation between CMV infection and the incidence of bronchogenic carcinoma.

METHODS: The study was conducted using a Health Insurance Portability and Accountability Act (HIPAA) compliant national database to identify patients both with and without histories of CMV infection using International Classification of Diseases (ICD-10 and ICD-9) codes. Access to the database was granted by Holy Cross Health, Fort Lauderdale for the purpose of academic research with standard statistical methods used to analyze the data. 14,319 patients were included in both the control and CMV-exposed groups and matched by age range and Charlson Comorbidity Index (CCI) scores.

RESULTS: The incidence of bronchogenic carcinoma was 1.69% (243/14,319 patients) in the CMV group and 6.08% (871/14,319 patients) in the control group. The difference was statistically significant by a p-value of less than 2.6x10

CONCLUSION: This study found a statistically significant correlation between a prior CMV infection and a reduced incidence of bronchogenic carcinoma. This study demonstrates the need for further investigation into how the tumor microenvironment and host immune system are altered by the presence of a latent CMV infection.

Comments

All authors have declared that no financial support was received from any organization for the submitted work

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

NSUWorks Citation

Rashid, Selena; Ardeljan, Amalia; Frankel, Lexi R.; Cardeiro, Matthew; Kim, Enoch; Nagel, Brittany M.; Takabe, Kazuaki; and Rashid, Omar, "Human Cytomegalovirus (CMV) Infection Associated With Decreased Risk of Bronchogenic Carcinoma: Understanding How a Previous CMV Infection Leads to an Enhanced Immune Response Against Malignancy." (2023). HPD Articles. 254.
https://nsuworks.nova.edu/hpd_facarticles/254

ORCID ID

0000-0002-3463-5018,

DOI

10.7759/cureus.37265

Copyright

2023 Rashid et al.