Marian C. Brady, Nursing, Midwifery, and Allied Health Professions Research Unit (NMAHP)
Myzoon Ali, Nursing, Midwifery, and Allied Health Professions Research Unit (NMAHP)
Kathryn VandenBerg, Nursing, Midwifery, and Allied Health Professions Research Unit (NMAHP)
Linda J. Williams, University of Edinburgh
Louise R. Williams, Nursing, Midwifery, and Allied Health Professions Research Unit (NMAHP)
Masahiro Abo, The Jikei University School of Medicine
Frank Becker, University of Oslo
Audrey Bowen, University of Manchester
Caitlin Brandenburg, The University of Queensland, Australia
Caterina Breitenstein, University of Muenster
Stefanie Bruehl, University of Manchester
David A. Copeland, The University of Queensland, Australia
Tamara B. Cranfill, Eastern Kentucky University
Marie di Pietro-Bachmann, University Hospitals and University of Geneva
Pamela Enderby, University of Sheffield
Joanne Fillingham, NHS Improvement, London
Federica Lucia Galli, Polytechnic University of Marche
Marialuisa Gandolfi, University of Verona
Bertrand Glize, University of Bordeaux
Erin Godecke, Edith Cowan University
Neil Hawkins, University of Glasgow
Katerina Hilari, University of London
Jackie Hinckley, Nova Southeastern UniversityFollow
Simon Horton, University of East Anglia
David Howard, Newcastle University
Petra Jaecks, Universitat Bielefeld
Elizabeth Jefferies, University of York
Luis M. T. Jesus, University of Aveiro
Maria Kambanaros, University of Technology, Limassol, Cyprus
Eun Kyoung Kang, Kangwon National University
Eman M. Khedr, Assiut University
Anthony Pak Hin Kong, University of Central Florida
Tarja Kukkonen, Tampere University Hospital
Marina Laganaro, University of Geneva
Matthew A. Lambon Ralph, University of Cambridge
Ann Charlotte Laska, Karolinska Institute
Beatrice Leemann, University of Geneva
Alexander P. Leff, Institute of Neurology, London
Roxele R. Lima, Educational Association Bom Jesus - IELUSC
Antje Lorenz, University of Berlin
Brian MacWhinney, Carnegie Mellon University
Rebecca Shisler Marshall, University of Georgia
Flavia Mattioli, ASST Spedali Civili of Brescia
Ilknur Mavis, Anadolu University
Marcus Meinzer, The University of Queensland, Australia
Reza Nilipour, University of Social Welfare and Rehabilitation Sciences
Enrique Noe, NEURORHB-Hospitales Vithas
Nam-Jong Paik, Seoul National University
Rebecca Palmer, University of Sheffield
Ilias Papathanasiou, Technological Educational Institute of Western Greece
Brigida F. Patricio, Polytechnic Institute of Porto
Isabel Pavão Martins, University of Lisbon, Portugal
Cathy Price, Wellcome Centre for Human Neuroimaging, UCL, London
Tatjana Prizl Jakovac, University of Zagreb
Elizabeth Rochon, University of Toronto
Miranda L. Rose, La Trobe University
Charlotte Rosso, Universite Paris-Sorbonne (Paris IV)
Ilona Rubi-Fessen, University of Cologne
Marina B. Ruiter, Radboud University Nijmegen
Claerwen Snell, Warrington Hospital
Benjamin Stahl, Charité Universitätsmedizin Berlin
Jerzy P. Szaflarski, University Of Alabama At Birmingham
Shirley A. Thomas, University of Nottingham
Mieke van de Sandt-Koenderman, Erasmus University of Rotterdam
Ineke van der Meulen, Erasmus University of Rotterdam
Evy Visch-Brink, Erasmus University of Rotterdam
Linda Worrall, The University of Queensland, Australia
Heather Harris Wright, East Carolina University

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Stroke, aphasia, complex intervention, IPD, meta-analysis







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Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis.

Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke.

Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions.

Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains.

Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke.

Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947)



This project was funded by the National Institute for Health Research (NIHR), Health Services and Delivery Research Programme [HS&DR–14/04/22] and will be published in full in the Health Services and Delivery Research Journal. Further information available at MCB is funded by the Chief Scientist Office (CSO), Scottish Government Health and Social Care Directorates. This article is based upon work from Collaboration of Aphasia Trialists supported by COST (European Cooperation in Science and Technology [IS1208 2013-2017]) and the Tavistock Trust for Aphasia (TTA) (2017–2020). This report presents independent research commissioned by the National Institute for Health Research (NIHR). The views and opinions expressed by the authors in this publication are those of the authors and do not necessarily reflect those of the National Health Service, the NIHR, NETSCC, the HS&DR programme, the CSO, COST, the TTA or the Department of Health.



Peer Reviewed