Document Type
Article
Publication Date
2020
Publication Title
Aphasiology
Keywords
Stroke, aphasia, complex intervention, IPD, meta-analysis
ISSN
0268-7038
Volume
34
Issue/No.
2
First Page
137
Last Page
157
Abstract
Background: Speech and language therapy (SLT) benefits people with aphasia following stroke. Group level summary statistics from randomised controlled trials hinder exploration of highly complex SLT interventions and a clinically relevant heterogeneous population. Creating a database of individual participant data (IPD) for people with aphasia aims to allow exploration of individual and therapy-related predictors of recovery and prognosis.
Aim: To explore the contribution that individual participant characteristics (including stroke and aphasia profiles) and SLT intervention components make to language recovery following stroke.
Methods and procedures: We will identify eligible IPD datasets (including randomised controlled trials, non-randomised comparison studies, observational studies and registries) and invite their contribution to the database. Where possible, we will use meta- and network meta-analysis to explore language performance after stroke and predictors of recovery as it relates to participants who had no SLT, historical SLT or SLT in the primary research study. We will also examine the components of effective SLT interventions.
Outcomes and results: Outcomes include changes in measures of functional communication, overall severity of language impairment, auditory comprehension, spoken language (including naming), reading and writing from baseline. Data captured on assessment tools will be collated and transformed to a standardised measure for each of the outcome domains.
Conclusion: Our planned systematic-review-based IPD meta- and network meta-analysis is a large scale, international, multidisciplinary and methodologically complex endeavour. It will enable hypotheses to be generated and tested to optimise and inform development of interventions for people with aphasia after stroke.
Systematic review registration: The protocol has been registered at the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42018110947)
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
NSUWorks Citation
Brady, Marian C.; Ali, Myzoon; VandenBerg, Kathryn; Williams, Linda J.; Williams, Louise R.; Abo, Masahiro; Becker, Frank; Bowen, Audrey; Brandenburg, Caitlin; Breitenstein, Caterina; Bruehl, Stefanie; Copeland, David A.; Cranfill, Tamara B.; di Pietro-Bachmann, Marie; Enderby, Pamela; Fillingham, Joanne; Galli, Federica Lucia; Gandolfi, Marialuisa; Glize, Bertrand; Godecke, Erin; Hawkins, Neil; Hilari, Katerina; Hinckley, Jackie; Horton, Simon; Howard, David; Jaecks, Petra; Jefferies, Elizabeth; Jesus, Luis M. T.; Kambanaros, Maria; Kang, Eun Kyoung; Khedr, Eman M.; Hin Kong, Anthony Pak; Kukkonen, Tarja; Laganaro, Marina; Lambon Ralph, Matthew A.; Laska, Ann Charlotte; Leemann, Beatrice; Leff, Alexander P.; Lima, Roxele R.; Lorenz, Antje; MacWhinney, Brian; Marshall, Rebecca Shisler; Mattioli, Flavia; Mavis, Ilknur; Meinzer, Marcus; Nilipour, Reza; Noe, Enrique; Paik, Nam-Jong; Palmer, Rebecca; Papathanasiou, Ilias; Patricio, Brigida F.; Martins, Isabel Pavão; Price, Cathy; Jakovac, Tatjana Prizl; Rochon, Elizabeth; Rose, Miranda L.; Rosso, Charlotte; Rubi-Fessen, Ilona; Ruiter, Marina B.; Snell, Claerwen; Stahl, Benjamin; Szaflarski, Jerzy P.; Thomas, Shirley A.; van de Sandt-Koenderman, Mieke; van der Meulen, Ineke; Visch-Brink, Evy; Worrall, Linda; and Wright, Heather Harris, "RELEASE: a protocol for a systematic review based, individual participant data, meta- and network meta-analysis, of complex speech-language therapy interventions for stroke-related aphasia" (2020). HPD Articles. 212.
https://nsuworks.nova.edu/hpd_facarticles/212
ORCID ID
DOI
10.1080/02687038.2019.1643003
Copyright
© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group
Comments
Funding
This project was funded by the National Institute for Health Research (NIHR), Health Services and Delivery Research Programme [HS&DR–14/04/22] and will be published in full in the Health Services and Delivery Research Journal. Further information available at https://www.aphasiatrials.org/RELEASE. MCB is funded by the Chief Scientist Office (CSO), Scottish Government Health and Social Care Directorates. This article is based upon work from Collaboration of Aphasia Trialists supported by COST (European Cooperation in Science and Technology [IS1208 2013-2017]) and the Tavistock Trust for Aphasia (TTA) (2017–2020). This report presents independent research commissioned by the National Institute for Health Research (NIHR). The views and opinions expressed by the authors in this publication are those of the authors and do not necessarily reflect those of the National Health Service, the NIHR, NETSCC, the HS&DR programme, the CSO, COST, the TTA or the Department of Health.