Document Type
Article
Publication Date
1-1-2020
Publication Title
Physiological Reports
Keywords
RAS-Fingerprint®, angiotensin converting enzyme (ACE), angiotensin converting enzyme 2 (ACE2), caloric reduction, inadequate food intake
ISSN
2051-817X
Volume
8
Issue/No.
1
First Page
e14338
Abstract
We previously showed that 2 weeks of a severe food restricted (sFR) diet (40% of the caloric intake of the control (CT) diet) up-regulated the circulating renin angiotensin (Ang) system (RAS) in female Fischer rats, most likely as a result of the fall in plasma volume. In this study, we investigated the role of the central RAS in the mean arterial pressure (MAP) and heart rate (HR) dysregulation associated with sFR. Although sFR reduced basal mean MAP and HR, the magnitude of the pressor response to intracerebroventricular (icv) microinjection of Ang-[1-8] was not affected; however, HR was 57 ± 13 bpm lower 26 min after Ang-[1-8] microinjection in the sFR rats and a similar response was observed after losartan was microinjected. The major catabolic pathway of Ang-[1-8] in the hypothalamus was via Ang-[1-7]; however, no differences were detected in the rate of Ang-[1-8] synthesis or degradation between CT and sFR animals. While sFR had no effect on the AT R binding in the subfornical organ (SFO), the organum vasculosum laminae terminalis (OVLT) and median preoptic nucleus (MnPO) of the paraventricular anteroventral third ventricle, ligand binding increased 1.4-fold in the paraventricular nucleus (PVN) of the hypothalamus. These findings suggest that sFR stimulates the central RAS by increasing AT R expression in the PVN as a compensatory response to the reduction in basal MAP and HR. These findings have implications for people experiencing a period of sFR since an activated central RAS could increase their risk of disorders involving over activation of the RAS including renal and cardiovascular diseases.
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
NSUWorks Citation
De Souza, Aline Maria; Linares, Andrea; Speth, Robert C.; Campos, Glenda V.; Ji, Hong; Chianca, Deoclécio; Sandberg, Kathryn; and De Menezes, Rodrigo C., "Severe food restriction activates the central renin angiotensin system" (2020). HPD Articles. 110.
https://nsuworks.nova.edu/hpd_facarticles/110
ORCID ID
0000-0002-6434-2150
DOI
10.14814/phy2.14338
Copyright
© 2020 The Authors.
