Faculty Articles

Title

What Is Old Is New Again: Delafloxacin, A Modern Fluoroquinolone

ISBN or ISSN

1875-9114

Location

United States

Publication Title

Pharmacotherapy

Volume

38

Issue

1

Date of original Performance / Presentation

10-23-2017

Publication Date / Copyright Date

1-2018

First Page

108

Last Page

121

Publisher

John Wiley & Sons, Inc.

DOI Number

10.1002/phar.2050

Abstract

Delafloxacin is a new fluoroquinolone antimicrobial approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs) in adults using dosage regimens of 300 mg intravenously every 12 hours, 450 mg orally every 12 hours, or switching from intravenous to oral regimens for a 5- to 14-day treatment duration. Dosage adjustments in patients with severe renal dysfunction (estimated glomerular filtration rate [eGFR] = 15-29 ml/min/1.73 m

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Keywords

administration, adult, anti-bacterial agents, bacterial, fluoroquinolones, gram-negative bacteria, gram-negative bacterial infections, gram-positive bacteria, gram-positive bacterial infections, humans, intravenous, oral, skin diseases

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