The Association of Vitamin D Deficiency and Glucose Control among Diabetic Patients
ISBN or ISSN
Saudi Pharmaceutical Journal
Publication Date / Copyright Date
To evaluate the association between the level of vitamin D and glycemic control among patients with diabetes.
Research design and method
We analyzed data collected from NHANES 2003–2006. We included only non-pregnant adult diabetic persons 18 years or older. Participants who had vitamin D level less than 20 ng/ml were considered as having vitamin D deficiency. Participants were considered to have a glucose control if the HbA1c level was less than 7% [53 mmol/L]. We used student’s t test to compare the difference in HbA1c means between people with Diabetes with and without a vitamin D deficiency. We used a multivariate logistic regression model to predict the relationship between glucose control and vitamin D deficiency. We used race/ethnicity, BMI, age, gender, type of diabetic medication used, having health insurance or not, and comorbid conditions (hypertension, anemia, cholesterol, liver disease, and kidney disease) as control variables.
The study population included a total of 929 non-institutionalized, non-pregnant, diabetic adult persons. About 57% of patients with diabetes had a vitamin D deficiency. Blacks (non-Hispanic patients) with diabetes had the highest rate of vitamin D deficiency (79%). The unadjusted means of HbA1c were significantly different between diabetic patients with no vitamin D deficiency and those with a vitamin D deficiency (7.06% [54 mmol/L], 7.56 % [59 mmol/L], respectively, P < 0.0001). Multivariate adjustment showed a small but not significant, increase in odds (11%) of having uncontrolled diabetes in patients with a vitamin D deficiency after adjustment for other factors.
Vitamin D deficiency is very common in patients with diabetes. We found no significant association between vitamin D level and glycemic control in patients with diabetes after adjustment for control variables.
Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
diabetes, glucose control, HbA1c, vitamin D deficiency
Almetwazi, Mansour; Noor, Ahmed; Almasri, Diena; Popovici, Ioana; Alhawassi, Tariq; Alburikan, Khalid A.; and Harrington, Catherine, "The Association of Vitamin D Deficiency and Glucose Control among Diabetic Patients" (2017). Faculty Articles. 50.