Faculty Articles

The Association of Vitamin D Deficiency and Glucose Control among Diabetic Patients

Publication Title

Saudi Pharmaceutical Journal

Publisher

Elsevier BV

ISSN

2213-7475

Publication Date

12-2017

Keywords

diabetes, glucose control, HbA1c, vitamin D deficiency

Abstract

Objective

To evaluate the association between the level of vitamin D and glycemic control among patients with diabetes.

Research design and method

We analyzed data collected from NHANES 2003–2006. We included only non-pregnant adult diabetic persons 18 years or older. Participants who had vitamin D level less than 20 ng/ml were considered as having vitamin D deficiency. Participants were considered to have a glucose control if the HbA1c level was less than 7% [53 mmol/L]. We used student’s t test to compare the difference in HbA1c means between people with Diabetes with and without a vitamin D deficiency. We used a multivariate logistic regression model to predict the relationship between glucose control and vitamin D deficiency. We used race/ethnicity, BMI, age, gender, type of diabetic medication used, having health insurance or not, and comorbid conditions (hypertension, anemia, cholesterol, liver disease, and kidney disease) as control variables.

Results

The study population included a total of 929 non-institutionalized, non-pregnant, diabetic adult persons. About 57% of patients with diabetes had a vitamin D deficiency. Blacks (non-Hispanic patients) with diabetes had the highest rate of vitamin D deficiency (79%). The unadjusted means of HbA1c were significantly different between diabetic patients with no vitamin D deficiency and those with a vitamin D deficiency (7.06% [54 mmol/L], 7.56 % [59 mmol/L], respectively, P < 0.0001). Multivariate adjustment showed a small but not significant, increase in odds (11%) of having uncontrolled diabetes in patients with a vitamin D deficiency after adjustment for other factors.

Conclusion

Vitamin D deficiency is very common in patients with diabetes. We found no significant association between vitamin D level and glycemic control in patients with diabetes after adjustment for control variables.

DOI

10.1016/j.jsps.2017.09.001

Volume

25

Issue

8

First Page

1179

Last Page

1183

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

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