Faculty Articles

Integrase Inhibitors: After 10 Years of Experience, Is the Best Yet to Come?

Publication Title

Pharmacotherapy

Publisher

Wiley

ISSN

1875-9114

Publication Date

5-1-2019

Keywords

antiretroviral therapy, HIV, Integrase inhibitors

Abstract

The era of the integrase strand transfer inhibitors (INSTIs) for the treatment of human immunodeficiency virus (HIV) infection began with raltegravir in 2007. Since that time, several other INSTIs have been introduced including elvitegravir, dolutegravir, and, most recently, bictegravir, that have shown great utility as part of antiretroviral regimens in both treatment-naive and treatment-experienced patients. At present, antiretroviral guidelines fully endorse the INSTI class as part of all first-line treatment regimens. After 10 years of experience with INSTIs, newer agents are on the horizon such as cabotegravir and MK-2048 for potential use as either HIV pre-exposure prophylaxis or maintenance therapy. This review provides a brief overview of the INSTI class including agents currently available and those still in development, reviews available data from both completed and ongoing clinical trials, and outlines simplification strategies using INSTIs.

DOI

10.1002/phar.2246

Volume

39

Issue

5

First Page

576

Last Page

598

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

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Peer Reviewed

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