Faculty Articles
Role of Paliperidone Palmitate 3-Monthly in the Management of Schizophrenia: Insights from Clinical Practice
Publication Title
Neuropsychiatric Disease and Treatment
Publisher
Dovepress
ISSN
1178-2021
Publication Date
2-11-2019
Keywords
antipsychotic, Invega, LAI, long-acting, Trinza
Abstract
Schizophrenia is a complex, chronic psychiatric disorder associated with reduced quality of life and shortened life span. The majority of patients with schizophrenia will relapse within 1 year following an acute episode. The ultimate goals of treatment are to improve functional capabilities, minimize residual symptoms during periods of remission, and decrease relapse frequency and duration, as each relapse brings with it the possibility of a worsening prognosis. Maintaining therapeutic continuity is essential for long-term, positive patient outcomes in schizophrenia. Medication nonadherence and symptomatic relapses magnify the disease burden associated with this disorder. Medication adherence in chronic disease states generally improves with a decrease in dosing frequency. Long-acting injectable (LAI) antipsychotics were developed to improve patient outcomes secondarily to improving medication adherence. Paliperidone palmitate 3-monthly injection (PP3M) is the only LAI available with a quarterly dosing interval. PP3M has been US Food and Drug Administration-approved for use in the long-term maintenance treatment of schizophrenia in patients already controlled on once-monthly PP LAI (paliperidone palmitate once-monthly injection [PP1M]) for a minimum of 4 months. As current evidence supports the efficacy and tolerability of PP3M compared to PP1M and placebo, PP3M appears to be a viable treatment option for patients previously maintained on PP1M. However, to truly establish the place of PP3M in therapy relative to other oral antipsychotics and LAIs, more research is needed. This narrative review aims briefly to describe the pharmacotherapeutic characteristics of PP3M and summarize current literature pertaining to the use of PP3M in the management of schizophrenia.
DOI
10.2147/NDT.S140383
Volume
15
First Page
449
Last Page
456
Disciplines
Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
NSUWorks Citation
Lopez, Alicia and Rey, Jose A., "Role of Paliperidone Palmitate 3-Monthly in the Management of Schizophrenia: Insights from Clinical Practice" (2019). Faculty Articles. 336.
https://nsuworks.nova.edu/hpd_corx_facarticles/336
