Faculty Articles

Angiotensin II Induces Interleukin-6 Expression in Astrocytes: Role of Reactive Oxygen Species and NF-κB

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Molecular and Cellular Endocrinology



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North Holland Publishing


Previously, we showed that the bio-peptide angiotensin (Ang) II induces interleukin-6 (IL-6) in cultured astrocytes; however, the mechanism(s) involved in this effect were unknown. In the current study, we determined in brainstem and cerebellum astrocytes from the spontaneously hypertensive rat (SHR), the effect of Ang II to induce IL-6 as well as reactive oxygen species (ROS) generation. Results from this study showed that Ang II significantly induced the differential expression of IL-6 mRNA and protein levels in astrocytes from both regions of Wistar and SHRs. There were differences in the ability of Ang II to induce IL-6 mRNA and protein levels, but these differences were not apparent at all time points examined. Ang II also induced ROS generation, but there were no significant differences between ROS generation in SHR samples as compared to the Wistar samples. Ang II-induced IL-6 levels were mediated via the AT


Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences


angiotensin II, animals, astrocytes, brain, female, gene expression regulation, hydrazones, imidazoles, inbred SHR, interleukin-6, losartan, messenger, NF-kappa B, nitroimidazoles, pyridines, rats, reactive oxygen species, RNA, time factors, Wistar

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