Faculty Articles

Title

β1-adrenoceptor Arg389Gly polymorphism confers differential β-arrestin-binding tropism in cardiac myocytes

Publication Title

Pharmacogenomics

Volume

17

Issue

15

Publication Date / Copyright Date

10-1-2016

First Page

1611

Last Page

1620

Abstract

AIM: The β

METHODS: We tested the β

RESULTS: βarr1 binds both variants upon isoproterenol, carvedilol or metoprolol treatment in neonatal rat ventricular myocytes. Conversely, the potentially beneficial in the heart βarr2 only interacts with the Arg389 receptor in response to isoproterenol or carvedilol.

CONCLUSION: Arg389 confers unique βarr2-interacting tropism to the β

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Keywords

Animals, Carbazoles, Carvedilol, Cells, Cultured, Isoproterenol, Myocytes, Cardiac, Polymorphism, Genetic, Propanolamines, Protein Binding, Rats, Rats, Wistar, Receptors, Adrenergic, beta-1, Tropism, beta-Arrestins

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