β1-adrenoceptor Arg389Gly polymorphism confers differential β-arrestin-binding tropism in cardiac myocytes

Authors

Katie A McCrink
Ava Brill
Malika Jafferjee
Thairy Reyes Valero
Christine Marrero
Martha M Rodriguez
Genevieve M. Hale, Nova Southeastern UniversityFollow
Anastasios Lymperopoulos, Nova Southeastern UniversityFollow

Publication Title

Pharmacogenomics

Publication Date

10-1-2016

Keywords

Animals, Carbazoles, Carvedilol, Cells, Cultured, Isoproterenol, Myocytes, Cardiac, Polymorphism, Genetic, Propanolamines, Protein Binding, Rats, Rats, Wistar, Receptors, Adrenergic, beta-1, Tropism, beta-Arrestins

Abstract

AIM: The β

METHODS: We tested the β

RESULTS: βarr1 binds both variants upon isoproterenol, carvedilol or metoprolol treatment in neonatal rat ventricular myocytes. Conversely, the potentially beneficial in the heart βarr2 only interacts with the Arg389 receptor in response to isoproterenol or carvedilol.

CONCLUSION: Arg389 confers unique βarr2-interacting tropism to the β

Volume

17

Issue

15

First Page

1611

Last Page

1620

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

NSUWorks Citation

McCrink, Katie A; Brill, Ava; Jafferjee, Malika; Valero, Thairy Reyes; Marrero, Christine; Rodriguez, Martha M; Hale, Genevieve M.; and Lymperopoulos, Anastasios, "β1-adrenoceptor Arg389Gly polymorphism confers differential β-arrestin-binding tropism in cardiac myocytes" (2016). Faculty Articles. 170.
https://nsuworks.nova.edu/hpd_corx_facarticles/170