Faculty Articles

Evaluating the Effectiveness of Atomoxetine for the Treatment of Primary Orthostatic Hypotension in Adults

Publication Title

Journal of clinical hypertension

Publisher

Wiley

ISSN

1751-7176

Publication Date

4-1-2018

Keywords

Adrenergic Uptake Inhibitors, Adult, Atomoxetine Hydrochloride, Dose-Response Relationship, Drug, Female, Humans, Hypotension, Orthostatic, Male, Observational Studies as Topic, Randomized Controlled Trials as Topic, Treatment Outcome

Abstract

In patients who have OH and in whom other treatment options have failed, atomoxetine may be a viable alternative. Atomoxetine raises BP dramatically at small doses, specifically doses at 18 mg. Atomoxetine significantly raises seated and standing SBP when compared with placebo and current standards of care such as midodrine. Atomoxetine has been shown to raise SBP only in patients with an intact central nervous system. Atomoxetine can be useful in patients with severe symptoms of OH or in patients with refractory OH. It is important that clinicians are aware of atomoxetine as a promising agent for the symptomatic management of patients with primary OH in whom conventional therapies have failed. It has been proven to be safe and effective, even in the elderly population.

DOI

10.1111/jch.13260

Volume

20

Issue

4

First Page

794

Last Page

797

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

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