Faculty Articles
PubMed Identifier
30324360
In Vivo Evaluation of Taste-Masked Fast-Disintegrating Sublingual Tablets of Epinephrine Microcrystals
Publication Title
AAPS PharmSciTech [electronic resource]
Publication Date
11-1-2018
Keywords
Administration, Sublingual, Anaphylaxis, Animals, Bronchodilator Agents, Drug Evaluation, Preclinical, Epinephrine, Excipients, Female, Injections, Intramuscular, Microspheres, Rabbits, Random Allocation, Tablets, Taste
Abstract
In community settings, IM injection of 0.3 mg epinephrine (Epi) using an auto-injector is the drug of choice for treatment of anaphylaxis. Previously, a taste-masking (TM) formulation of fast-disintegrating sublingual tablets (FDSTs) was developed in our lab. Also, Epi was micronized (Epi-MC) successfully and reduced the previously achieved bioequivalent sublingual Epi dose to 0.3 mg IM injection by half using non-taste-masked fast-disintegrating sublingual tablets (TM-FDSTs). Our objective for this study was to evaluate the sublingual absorption of Epi-MC using TM-FDST. These sublingual Epi tablets have potential for out-of-hospital treatment of anaphylaxis and are suitable for human studies. TM-FDSTs containing Epi-MC were manufactured by direct compression. The rate and extent of Epi absorption from our developed 20 mg Epi-MC-TM-FDSTs (n = 5) were evaluated in rabbits and compared to the previous result from 20 mg Epi-MC in non-TM-FDSTs and EpiPen® auto-injector. Blood samples were collected over 1 h, and Epi concentrations were measured using HPLC with electrochemical detection. Mean ± SEM AUC
DOI
10.1208/s12249-018-1171-4
Volume
19
Issue
8
First Page
3886
Last Page
3894
Disciplines
Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
NSUWorks Citation
Rachid, Ousama; Simons, Keith J; and Rawas-Qalaji, Mutasem, "In Vivo Evaluation of Taste-Masked Fast-Disintegrating Sublingual Tablets of Epinephrine Microcrystals" (2018). Faculty Articles. 139.
https://nsuworks.nova.edu/hpd_corx_facarticles/139