Faculty Articles

Epinephrine in Anaphylaxis: Preclinical Study of Pharmacokinetics after Sublingual Administration of Taste-Masked Tablets for Potential Pediatric Use

Publication Title

Pharmaceutics

Volume

10

Issue

1

Publication Date / Copyright Date

2-11-2018

DOI Number

10.3390/pharmaceutics10010024

Abstract

Epinephrine is a life-saving treatment in anaphylaxis. In community settings, a first-aid dose of epinephrine is injected from an auto-injector (EAI). Needle phobia highly contributes to EAI underuse, leading to fatalities-especially in children. A novel rapidly-disintegrating sublingual tablet (RDST) of epinephrine was developed in our laboratory as a potential alternative dosage form. The aim of this study was to evaluate the sublingual bioavailability of epinephrine 30 mg as a potential pediatric dose incorporated in our novel taste-masked RDST in comparison with intramuscular (IM) epinephrine 0.15 mg from EAI, the recommended and only available dosage form for children in community settings. We studied the rate and extent of epinephrine absorption in our validated rabbit model (

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Keywords

adrenaline; allergy; anaphylaxis; auto-injector; bioavailability; bioequivalence; epinephrine; intramuscular; rapidly-disintegrating; sublingual delivery; tablets

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