Faculty Articles

PubMed Identifier

17520443

Fast-disintegrating sublingual epinephrine tablets: effect of tablet dimensions on tablet characteristics.

Publication Title

Drug development and industrial pharmacy

Volume

33

Issue

5

Publication Date / Copyright Date

5-1-2007

First Page

523

Last Page

530

Abstract

The purpose of this study was to evaluate the effect of changing dimensions on the hardness (H), disintegration time (DT), and wetting time (WT) of fast-disintegrating epinephrine tablets for sublingual administration as potential first aid treatment for anaphylaxis. Tablet formulations I and II, containing 0% and 10% epinephrine bitartrate, respectively, and weighing 150 mg were prepared by direct compression. Formulations were compressed at a range of forces using an 8/32'' die with concave punches (CP); a 10/32'' and an 11/32'' die with CP and flat punches (FP). Tablet weight variation, content uniformity, thickness, H, DT, and WT were measured. The 8/32'', 10/32'', and 11/32'' dies resulted in tablet thickness of ranges 0.25-0.19'', 0.17-0.1'', and 0.16-0.08'', respectively. The DT and WT using the 8/32'' die were

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Keywords

Administration, Sublingual, Anaphylaxis, Chemistry, Pharmaceutical, Epinephrine, First Aid, Hardness, Humans, Rheology, Surface Properties, Sympathomimetics, Tablets, Wettability

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Peer Reviewed

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