Fast-disintegrating sublingual tablets: effect of epinephrine load on tablet characteristics
AAPS PharmSciTech [electronic resource]
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The aim of this study was to evaluate the effect of increasing epinephrine load on the characteristics of fast-disintegrating sublingual tablets for the potential emergency treatment of anaphylaxis. Four tablet formulations, A, B, C, and D, containing 0%, 6%, 12%, and 24% of epinephrine bitartrate, respectively, and microcrystalline cellulose:low-substituted hydroxypropyl cellulose (9:1), were prepared by direct compression, at a range of compression forces. Tablet weight variation, content uniformity, hardness, disintegration time, wetting time, and friability were measured for each formulation at each compression force. All 4 tablet formulations at each compression force were within the United States Pharmacopeia (USP) limits for weight variation and content uniformity. A linear increase in compression force resulted in an exponential increase in hardness for all formulations, a linear increase in disintegration and wetting times of A, and an exponential increase in disintegration and wetting times of B, C, and D. At a mean +/- SD hardness of > or = 2.3 +/- 0.2 kg, all tablet formulations passed the USP friability test. At a mean +/- SD hardness of < or = 3.1 +/- 0.2 kg, all tablet formulations resulted in disintegration and wetting times of
Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
Administration, Oral, Anaphylaxis, Animals, Chemistry, Pharmaceutical, Coated Materials, Biocompatible, Diffusion, Drug Evaluation, Preclinical, Epinephrine, Hardness, Humans, Kinetics, Materials Testing, Particle Size, Saliva, Solubility, Surface Properties, Tablets, Time Factors, Tongue
Qalaji, Mutasem Rawas; Simons, F Estelle R; and Simons, Keith J, "Fast-disintegrating sublingual tablets: effect of epinephrine load on tablet characteristics" (2006). Faculty Articles. 121.