Faculty Articles

Fast-disintegrating sublingual tablets: effect of epinephrine load on tablet characteristics

Publication Title

AAPS PharmSciTech [electronic resource]

Publisher

Springer Nature

Publication Date

4-28-2006

Keywords

Administration, Oral, Anaphylaxis, Animals, Chemistry, Pharmaceutical, Coated Materials, Biocompatible, Diffusion, Drug Evaluation, Preclinical, Epinephrine, Hardness, Humans, Kinetics, Materials Testing, Particle Size, Saliva, Solubility, Surface Properties, Tablets, Time Factors, Tongue

Abstract

The aim of this study was to evaluate the effect of increasing epinephrine load on the characteristics of fast-disintegrating sublingual tablets for the potential emergency treatment of anaphylaxis. Four tablet formulations, A, B, C, and D, containing 0%, 6%, 12%, and 24% of epinephrine bitartrate, respectively, and microcrystalline cellulose:low-substituted hydroxypropyl cellulose (9:1), were prepared by direct compression, at a range of compression forces. Tablet weight variation, content uniformity, hardness, disintegration time, wetting time, and friability were measured for each formulation at each compression force. All 4 tablet formulations at each compression force were within the United States Pharmacopeia (USP) limits for weight variation and content uniformity. A linear increase in compression force resulted in an exponential increase in hardness for all formulations, a linear increase in disintegration and wetting times of A, and an exponential increase in disintegration and wetting times of B, C, and D. At a mean +/- SD hardness of > or = 2.3 +/- 0.2 kg, all tablet formulations passed the USP friability test. At a mean +/- SD hardness of < or = 3.1 +/- 0.2 kg, all tablet formulations resulted in disintegration and wetting times of

DOI

10.1208/pt070241

Volume

7

Issue

2

First Page

41

Last Page

41

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Link to Full Text
Peer Reviewed

Find in your library

Share

COinS