Faculty Articles

Title

Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways

Publication Title

Endocrine

Volume

66

Issue

2

Publication Date / Copyright Date

11-1-2019

First Page

349

Last Page

359

Publisher

Springer Nature

DOI Number

10.1007/s12020-019-01930-z

Abstract

PURPOSE: To study the ability of a novel bovine serum albumin-angiotensin II (BSA-Ang II) conjugate to effect responses of the AT

METHODS: Angiotensin II (Ang II) was conjugated with bovine serum albumin and compared with Ang II for competition binding to AT

RESULTS: The BSA-Ang II conjugate was less potent competing for AT

CONCLUSIONS: Addition of a high molecular weight molecule to Ang II reduced its AT

Disciplines

Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences

Keywords

AT1 receptor; Aldosterone release; Biased agonism; Bovine serum albumin-conjugated angiotensin II; Calcium mobilization; Salt appetite

Peer Reviewed

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