Faculty Articles
Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways
Publication Title
Endocrine
Publisher
Springer Nature
ISSN
1355-008X
Publication Date
11-1-2019
Keywords
AT1 receptor; Aldosterone release; Biased agonism; Bovine serum albumin-conjugated angiotensin II; Calcium mobilization; Salt appetite
Abstract
PURPOSE: To study the ability of a novel bovine serum albumin-angiotensin II (BSA-Ang II) conjugate to effect responses of the AT
METHODS: Angiotensin II (Ang II) was conjugated with bovine serum albumin and compared with Ang II for competition binding to AT
RESULTS: The BSA-Ang II conjugate was less potent competing for AT
CONCLUSIONS: Addition of a high molecular weight molecule to Ang II reduced its AT
DOI
10.1007/s12020-019-01930-z
Volume
66
Issue
2
First Page
349
Last Page
359
Disciplines
Medicine and Health Sciences | Pharmacy and Pharmaceutical Sciences
NSUWorks Citation
Pang, Hong Weng; Linares, Andrea; Couling, Leena; Santollo, Jessica; Ancheta, Leonardo; Daniels, Derek; and Speth, Robert Charles, "Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways" (2019). Faculty Articles. 117.
https://nsuworks.nova.edu/hpd_corx_facarticles/117
Rights
© Springer Science + Business Media, LLC, part of Springer Nature 2019
Additional Comments
This study was funded by a President’s Faculty Research Development Grant from Nova Southeastern University and the Cardiovascular Neuroscience Fund, Nova Southeastern University and NIH, HL-113905.