Department of Nutrition Student Projects

Submission Date

4-13-2026

Document Type

Undergraduate Project

Degree Name

Bachelor of Science in Human Nutrition (BSHN)

First Mentor

Dr. Andrea Charvet

Keywords

GLP-1 Receptor Agonists, Mediterranean Diet, Weight Maintenance, Medication Discontinuation, Longitudinal Prospective Study, Type 2 Diabetes, Weight Regain

Abstract

Glucagon-like peptide-1 (GLP-1) receptor agonists are effective for short-term weight reduction in adults with obesity, yet weight regain is frequent after discontinued use of the medication. Identifying sustainable dietary approaches that support long-term weight maintenance is imperative. The Mediterranean diet has been associated with improving metabolic health and resistant weight control, suggesting it may be an effective strategy for the transition off GLP-1 therapy. Men and women ages 45-55 that are diagnosed with Type 2 diabetes and receiving GLP-1 receptor therapy are the targets of this study, specifically those who plan to discontinue medication within the next three months. On this longitudinal prospective intervention, participants will be followed over four years to evaluate the effectiveness of the Mediterranean diet intervention in supporting weight maintenance after discontinuation of GLP-1 receptor agonists.

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