Department of Nutrition Student Projects

Copyright Statement

All rights reserved. This publication is intended for use solely by faculty, students, and staff of Nova Southeastern University. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, now known or later developed, including but not limited to photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author or the publisher.

Submission Date

9-20-2025

Document Type

Capstone

Degree Name

Master of Nutrition Science (MS)

First Mentor

Stephanie Petrosky, D.C.N.

Keywords

nutrition, capstone, NAFLD, magnesium, zinc, deficiency, mineral, trace-mineral, inflammation, IL-6, cytokine, liver, cirrhosis, Mediterranean Diet

Abstract

The prevalence and incidence of Non-Alcoholic Fatty Liver Disease (NAFLD) is rising. In the United States alone, the prevalence of NAFLD is currently 38% and there has been a 50% increase over the last three decades. The present study investigated the role of ultratrace mineral deficiencies, specifically magnesium (Mg) and zinc (Zn), and if so, what nutritional interventions could be made to ameliorate or protect against the development of NAFLD. The role of trace and ultratrace minerals in pro-inflammatory cytokine pathways contributing to NAFLD, specifically Interleukin-6 (IL-6), were investigated. IL-6 is produced by hepatocytes and plays a crucial role in hepatocyte homeostasis and overall hepatic health.2 NAFLD can progress to irreversible cirrhosis, ascites, jaundice, hepatic encephalopathy, and eventually decompensated liver failure. Given the great financial and personal costs of chronic illness and the rising genre of literature surrounding nutrition and NAFLD, consistent evidence as to a correct dietary approach is a key factor in improving patient outcomes and cirrhosis prevention. This review incorporated evidence from previous reviews, analyses, and randomized-controlled trials (RCTs) to summarize key successful dietary and nutrient interventions in NAFLD patients, specifically addressing Mg and Zn. Despite the progress in determining the relevance between ultratrace mineral homeostasis, diet, and NAFLD further research is necessary to understand the role and interactions of other nutrients, the effects in larger sample sizes, and the long-term effects of these interventions in NAFLD.

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