Faculty Articles
Glycophorin A as a Biological Dosimeter for Radiation Dose to the Bone Marrow from Iodine-131
Publication Title
Radiation Research
ISSN
0033-7587
Publication Date
6-1-1997
Abstract
The frequency of peripheral blood erythrocyte variants exhibiting allelic loss of glycophorin A (N/M antigen) has been used previously as a biological dosimeter to assess somatic mutations in bone marrow cells from external whole-body irradiation. The aim of the present study was to determine whether this marker could be used as a measure of bone marrow genotoxicity induced by 131I in the treatment of thyroid cancer. Flow cytometry of immunolabeled erythrocytes was performed to enumerate glycophorin A variants before and after eight therapy doses of 131I administered to five patients with differentiated thyroid carcinoma. Bone marrow radiation exposure from each dose was calculated from the integrated retention of 131I in the whole body and in the blood. In addition, the accumulated dose to the bone marrow received from earlier 131I therapy was calculated for each patient. Regression analysis was performed on the frequency of two glycophorin A variant cell types (N/O and N/N) as a function of accumulated dose to the bone marrow. Frequency of N/O variant cells showed a significant dose-related increase with a slope of 10.9 x 10(-6) per sievert. This dose effect is about one-half that previously observed after whole-body external irradiation at high dose rate. This decreased response could be explained by the low dose rate of the radiation to the bone marrow from 131I.
DOI
10.2307/3579490
Volume
147
Issue
6
Disciplines
Medical Specialties | Medicine and Health Sciences | Osteopathic Medicine and Osteopathy
NSUWorks Citation
Jensen, Ronald H.; Reynolds, James C.; Robbins, Jacob; Bigbee, William L.; Grant, Stephen G.; Langlois, Richard G.; Pineda, J Desiree; Lee, Taisheng; and Barker, W Craig, "Glycophorin A as a Biological Dosimeter for Radiation Dose to the Bone Marrow from Iodine-131" (1997). Faculty Articles. 905.
https://nsuworks.nova.edu/hpd_com_faculty_articles/905